Related Experiment Video
Updated: Mar 25, 2026

Induction of Periodontitis via a Combination of Ligature and Lipopolysaccharide Injection in a Rat Model
Published on: February 17, 2023
Cementogenesis in Patients with Localized Aggressive Periodontitis
Mojgan Paknejad1, Afshin Khorsand1, Siamak Yaghobee2
1Associate Professor, Dental Research Center, Dentistry Research Institute, Tehran University of Medical Sciences, Tehran, Iran; Department of Periodontics, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran.
Objectives:
The aim of this study was to determine the cementum thickness in the first molars of patients with localized aggressive periodontitis (LAP) compared to healthy individuals.
Materials And Methods:
This case-control study compared eight first molar teeth affected by LAP with eight third molar teeth of healthy individuals. The teeth were disinfected by immersion in 10% buffered formalin solution for three days and were then sectioned. External mesial root surfaces (middle one-third) were evaluated under a stereomicroscope by a blinded pathologist to determine the mean thickness of cementum. SPSS software (version 16.0) and t-test were used for statistical analysis.
Results:
Histological examination revealed a significant difference between the two groups in terms of the amount of cementogenesis (P<0.001) .The thickness of cementum was higher in the control group (105.16±11.5 μm) than in LAP patients (86.44±7.3 μm).
Conclusion:
This study demonstrated the presence of cementum hypoplasia in mesial root surfaces of first molars affected by LAP.

