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Assessment of Vascular Function in Patients With Chronic Kidney Disease
08:50

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

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Proinflammatory CD14(+)CD16(+) monocytes are associated with vascular stiffness in predialysis patients with chronic

Jae-Won Lee1, Eunjung Cho1, Myung-Gyu Kim1

  • 1Division of Nephrology, Department of Internal Medicine, Korea University, Anam Hospital, Seoul, Korea.

Kidney Research and Clinical Practice
|February 16, 2016
PubMed

Insights

The proinflammatory CD14(+)CD16(+) monocyte subset expands in chronic kidney disease (CKD) patients, correlating with inflammation and cardiovascular risks. This expansion contributes to inflammation, malnutrition, and atherosclerosis in CKD.

Area of Science:

  • Immunology
  • Nephrology
  • Cardiology

Background:

  • Chronic inflammation is a hallmark of chronic kidney disease (CKD), exacerbating cardiovascular disease (CVD) risk.
  • Monocytes, key immune cells, exist in subtypes including proinflammatory CD14(+)CD16(+) cells.
  • The role of monocyte subset expansion in predialysis CKD pathogenesis is unclear.

Purpose of the Study:

  • To investigate the expansion of proinflammatory CD14(+)CD16(+) monocytes in predialysis CKD patients.
  • To determine associations between this monocyte subset expansion and systemic inflammation markers.
  • To explore correlations with cardiovascular risk factors in CKD.

Main Methods:

  • Flow cytometry was used to quantify CD14(+)CD16(+) monocyte percentages in 111 predialysis CKD patients.
  • Analysis included comparisons with brachial-ankle pulse wave velocity (baPWV), plasma cytokine levels, and clinical parameters.

Main Results:

  • CD14(+)CD16(+) monocyte proportion was higher in advanced CKD stages and correlated with elevated Interleukin-6.
  • Monocyte expansion positively correlated with high-sensitive C-reactive protein and negatively with albumin, hemoglobin, and 25(OH)-vitamin D.
  • Expansion of CD14(+)CD16(+) monocytes independently predicted baPWV in diabetic CKD patients.

Conclusions:

  • Expansion of proinflammatory CD14(+)CD16(+) monocytes is a significant finding in predialysis CKD.
  • This monocyte subset expansion contributes to chronic inflammation, malnutrition, and atherosclerosis in CKD patients.
  • Targeting this monocyte subset may offer therapeutic potential for managing CKD complications.
Abstract

Keywords:
Chronic inflammationChronic kidney diseaseMonocyteVascular stiffness

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