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Diagnosis of Hirschsprung's Disease by Immunostaining Rectal Suction Biopsies for Calretinin, S100 Protein and Protein Gene Product 9.5
Published on: April 26, 2019
Recurrent Pediatric Perianal Swelling
Insights
Pediatric inflammatory bowel disease, including Crohn's disease and ulcerative colitis, presents with gastrointestinal symptoms. Treatment for perianal Crohn's disease combines surgical approaches with immunomodulators and biologics.
Area of Science:
- Gastroenterology
- Pediatric Inflammatory Bowel Disease (IBD)
Background:
- Pediatric inflammatory bowel disease (IBD) encompasses Crohn's disease (CD) and ulcerative colitis (UC), sharing symptoms like abdominal pain and diarrhea.
- CD can manifest with complex perianal conditions, including abscesses and fistulas.
Abstract:
Pediatric inflammatory bowel disease is a chronic gastrointestinal disease consisting of Crohn's disease (CD) and ulcerative colitis (UC). Both disease processes can share similar clinical symptoms including abdominal pain, diarrhea, hematochezia, and weight loss; CD can also be complicated by penetrating and fistulizing disease. Perianal skin tags, perianal abscesses, recto-cutaneous fistulae, and rectal stenosis are among the phenotypic characteristics of perianal CD. Current treatment strategies are focused on the surgical drainage of abscesses and the closure of fistulous tracts as well as controlling intestinal inflammation with the use of immunomodulators (6-mercaptopurine and methotrexate) and biologics (infliximab and adalimumab). Current guidelines by the American Gastroenterology Association and the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition recommend a combination of surgical intervention and medical management for the treatment of perianal CD.
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