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Bifunctional ultraviolet/ultrasound responsive composite TiO2/polyelectrolyte microcapsules.

Hui Gao1, Dongsheng Wen2, Nadezda V Tarakina1

  • 1The School of Engineering and Materials Science, Queen Mary, University of London, Mile End Road, London, E1 4NS, UK. g.sukhorukov@qmul.ac.uk.

Nanoscale
|February 16, 2016
PubMed
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Researchers developed strong, multifunctional microcapsules using titanium dioxide nanoparticles. These capsules respond to UV and ultrasound for controlled release, showing potential for drug delivery applications.

Area of Science:

  • Materials Science
  • Nanotechnology
  • Biomedical Engineering

Background:

  • Multifunctional microcapsules are crucial for controlled release applications.
  • Existing microcapsules often lack mechanical strength for harsh environments.
  • External triggers like UV and ultrasound offer precise control over release.

Purpose of the Study:

  • To fabricate composite microcapsules with enhanced mechanical strength and dual UV/ultrasound responsiveness.
  • To investigate the in-situ formation and reinforcing effects of needle-like TiO2 nanoparticles (NPs) within polyelectrolyte (PE) shells.
  • To evaluate the controlled release capabilities and biocompatibility of the developed TiO2/PE microcapsules.

Main Methods:

  • In-situ synthesis of needle-like TiO2 NPs within layer-by-layer (LbL) polyelectrolyte (PE) shells via titanium butoxide (TIBO) hydrolysis.

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  • Characterization of capsule morphology and mechanical properties using Scanning Electron Microscopy (SEM).
  • Assessment of UV and ultrasound responsiveness, controlled dextran release studies, and biocompatibility testing (MTT assay).

    • Main Results:

    • Fabrication of robust TiO2/PE composite microcapsules with excellent mechanical strength.
    • Demonstrated irreversible shell rupture upon exposure to UV or ultrasound.
    • Confirmed UV- and ultrasound-dependent dextran release from the microcapsules.
    • Verified biocompatibility of the amorphous TiO2-incorporated capsules.

    Conclusions:

    • The developed TiO2/PE microcapsules offer a promising platform for stimuli-responsive controlled drug delivery.
    • The in-situ formation of TiO2 NPs enhances mechanical integrity and provides dual external trigger functionalities.
    • These microcapsules exhibit significant potential for medicinal applications requiring precise and robust release systems.