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Cefetamet pivoxil in paediatric patients suffering from lower respiratory tract infections

M Gatzola-Karaveli1, N Vogiatzis, I Rousso

  • 1AHEPA University Hospital, Department of Paediatric Medicine, Thessaloniki, Greece.

Pharmatherapeutica
|January 1, 1989
PubMed

Insights

Cefetamet pivoxil effectively treated lower respiratory tract infections in children, showing better outcomes than cefaclor. This antibiotic is a promising option for pediatric pneumonia.

Area of Science:

  • Pediatric Infectious Diseases
  • Pharmacology and Therapeutics

Background:

  • Lower respiratory tract infections (LRTI) are common in children.
  • Antibiotic resistance necessitates evaluating alternative treatments for pediatric LRTI.

Purpose of the Study:

  • To compare the efficacy and safety of cefetamet pivoxil versus cefaclor in treating pediatric lower respiratory tract infections.

Main Methods:

  • A prospective, randomized comparative trial involving 31 children with LRTI.
  • Children received either cefetamet pivoxil (20 or 40 mg/kg/day) or cefaclor (30 mg/kg/day) for 7 days.

Main Results:

  • All patients receiving cefetamet pivoxil showed symptom resolution and normalized X-ray findings and leucocytosis.
  • One child on cefaclor deteriorated from bronchopneumonia to pneumonitis.
  • Vomiting led to treatment discontinuation in one patient on high-dose cefetamet pivoxil.

Conclusions:

  • Cefetamet pivoxil demonstrated significant clinical efficacy in pediatric LRTI.
  • Cefetamet pivoxil appears to be a safe and effective alternative to cefaclor for treating pediatric pneumonia.

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