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Carotid Atherosclerosis in Adult Patients with Persistently Active Juvenile Idiopathic Arthritis Compared with

Kristin Evensen1, Hanne Aaserud Aulie2, Ole Morten Rønning2

  • 1From the Department of Neurology, and Department of Rheumatology, Oslo University Hospital, Rikshospitalet; University of Oslo, Oslo; Medical Division, Akershus University Hospital, Lorenskog, Norway.K. Evensen, MD, Department of Neurology, Oslo University Hospital, Rikshospitalet, and University of Oslo; H.A. Aulie, MD, Department of Rheumatology, Oslo University Hospital, Rikshospitalet, and University of Oslo; O.M. Rønning, MD, PhD, Medical Division, Akershus University Hospital, and University of Oslo; B. Flatø, MD, PhD, Department of Rheumatology, Oslo University Hospital, Rikshospitalet, and University of Oslo; D. Russell, MD, PhD, FRCPE, Department of Neurology, Oslo University Hospital, Rikshospitalet, and University of Oslo. kristin@str.no.

The Journal of Rheumatology
|February 17, 2016
PubMed

Insights

Adults with long-term active Juvenile Idiopathic Arthritis (JIA) showed no increased risk of cardiovascular disease (CVD) as measured by carotid intima-media thickness (IMT). This study found similar IMT values in JIA patients and healthy controls.

Area of Science:

  • Rheumatology
  • Cardiology
  • Pediatric Rheumatology

Background:

  • Juvenile Idiopathic Arthritis (JIA) is a common childhood inflammatory rheumatic disease.
  • JIA is associated with a potential increased risk of cardiovascular disease (CVD).
  • Carotid intima-media thickness (IMT) and stenosis are surrogate markers for CVD.

Purpose of the Study:

  • To assess carotid intima-media thickness (IMT) and carotid stenosis in adults with long-term active JIA.
  • To compare these surrogate markers of CVD between JIA patients and healthy controls.

Main Methods:

  • Seventy-five adult JIA patients (age 28-45) with persistently active disease for over 15 years were reexamined.
  • A comparison group of 75 age- and sex-matched healthy controls was included.
  • Color duplex ultrasound of carotid arteries was used to measure IMT and detect stenosis.

Main Results:

  • No statistically significant difference in carotid IMT was found between JIA patients and controls (0.56 mm ± 0.09 vs 0.58 mm ± 0.07, p = 0.289).
  • Higher disease activity in JIA patients correlated with increased IMT, but this did not reach statistical significance compared to controls.
  • No carotid stenoses were detected in either group.

Conclusions:

  • Adults with long-term active JIA exhibit similar carotid intima-media thickness (IMT) compared to healthy controls.
  • The study suggests no elevated risk for early atherosclerosis as measured by IMT in this JIA cohort.
  • Further research may be needed to fully elucidate long-term cardiovascular risk in JIA.
Abstract

Keywords:
ATHEROSCLEROSISCAROTID IMTCAROTID ULTRASOUNDJUVENILE IDIOPATHIC ARTHRITIS

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