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High-Resolution Mapping of the Desmosomal Plaque and Adhesive Interface

David S Rubenstein1

  • 1Department of Dermatology and Lineberger Comprehensive Cancer Center, University of North Carolina-Chapel Hill School of Medicine, Chapel Hill, North Carolina, USA.

The Journal of Investigative Dermatology
|February 17, 2016
PubMed
Abstract

No abstract available in PubMed .

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The term desmosome derives from the Greek words "desmo" and "soma" meaning "adhesion bodies." This structure was first observed during the late 1800s and described as small, dense nodules in the epidermis. Desmosomes are button-like structures that help form an interlinked network of intermediate filaments across the cells. These junctions are  essential to hold cells together under mechanical stress and to maintain tissue integrity. Desmosomes are multi-protein...
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