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Related Concept Videos

Psychoneuroimmunology: Diabetes and Cancer01:19

Psychoneuroimmunology: Diabetes and Cancer

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Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
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Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
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Pathophysiology of Diabetes01:20

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Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
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The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
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Updated: Mar 25, 2026

Protocol to Create Chronic Wounds in Diabetic Mice
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Diabetes and cancer, common threads and missing links.

Fang Hua1, Jiao-Jiao Yu1, Zhuo-Wei Hu1

  • 1Immunology and Cancer Pharmacology Group, State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100050, China.

Cancer Letters
|February 17, 2016
PubMed
Summary

Diabetes and cancer share common risk factors and mechanisms like obesity and inflammation. Understanding these links is key for preventing and treating both diseases.

Keywords:
AutophagyER-stressHyperinsulinemiaInflammationInsulin resistanceObesity

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Area of Science:

  • Endocrinology
  • Oncology
  • Epidemiology

Background:

  • Diabetes mellitus is a global health concern with severe complications.
  • Growing evidence links diabetes, its risk factors, and medications to increased cancer incidence.
  • Potential mechanisms include insulin resistance, inflammation, metabolic dysregulation, and autophagy.

Purpose of the Study:

  • To review evidence supporting the diabetes-cancer relationship.
  • To explore underlying pathophysiological mechanisms.
  • To discuss the impact of diabetes treatments on cancer risk and prognosis.

Main Methods:

  • Literature review of epidemiological and clinical studies.
  • Analysis of proposed pathophysiological pathways.
  • Examination of data on anti-diabetic medications and cancer outcomes.

Main Results:

  • Diabetes is associated with a higher incidence of cancer.
  • Shared risk factors like obesity contribute to this link.
  • Anti-diabetic drugs may influence cancer risk and mortality.

Conclusions:

  • The relationship between diabetes and cancer is multifactorial.
  • Understanding these connections is vital for developing prevention and treatment strategies.
  • Further research into diabetes treatments' effects on cancer is warranted.