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Updated: Mar 25, 2026

Using a Murine Model of Psychosocial Stress in Pregnancy as a Translationally Relevant Paradigm for Psychiatric Disorders in Mothers and Infants
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Depression During Pregnancy and Postpartum.

Madeleine Becker1, Tal Weinberger2, Ann Chandy3

  • 1Department of Psychiatry and Human Behavior, Thomas Jefferson University Hospital, 1020 Sansom Street, Thompson Bldg, Suite 1652, Philadelphia, PA, 19107, USA. Madeleine.Becker@jefferson.edu.

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PubMed
Summary
This summary is machine-generated.

Peripartum depression poses risks to both mother and infant. Antidepressant use during pregnancy and postpartum requires careful risk-benefit assessment for maternal and infant well-being.

Keywords:
AntidepressantsDepressionLactationPostpartum depressionPregnancy

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Area of Science:

  • Perinatal mental health
  • Pharmacology in pregnancy
  • Neonatal adaptation

Background:

  • Depression frequently complicates pregnancy and the postpartum period.
  • A history of depression is a significant risk factor for peripartum mood disorders.
  • Both maternal depression and antidepressant use pose risks to the infant.

Purpose of the Study:

  • To review the risks associated with maternal depression during pregnancy and postpartum.
  • To examine the potential adverse effects of antidepressant medications on the infant.
  • To discuss the compatibility of antidepressants with breastfeeding and the overall risk-benefit balance.

Main Methods:

  • Literature review of studies on maternal depression and antidepressant use in pregnancy and postpartum.
  • Analysis of associations between maternal depression and infant outcomes.
  • Evaluation of infant risks linked to antidepressant exposure, including specific drug effects.
  • Assessment of breastfeeding compatibility with common antidepressant medications.

Main Results:

  • Maternal depression linked to preterm birth, low birth weight, fetal growth restriction, and postnatal cognitive/emotional issues.
  • Antidepressant exposure associated with preterm birth, reduced birth weight, persistent pulmonary hypertension, and postnatal adaptation syndrome (PNAS).
  • Paroxetine specifically linked to cardiac malformations; potential link to autism spectrum disorder noted.
  • Most antidepressants are found in low levels in breast milk and generally compatible with breastfeeding.

Conclusions:

  • The decision to use antidepressants during pregnancy and postpartum necessitates a thorough evaluation of risks versus the benefits of treating maternal depression.
  • Untreated maternal depression carries significant risks for both mother and child.
  • While antidepressants can pose risks, many are compatible with breastfeeding, and their use must be individualized.