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Related Experiment Videos

Aspergillus necrotizing retinitis. A clinico-pathologic study and review.

R D Bodoia1, J L Kinyoun, Q L Lou

  • 1Department of Ophthalmology, University of Washington School of Medicine, Seattle.

Retina (Philadelphia, Pa.)
|January 1, 1989
PubMed
Summary

A rare case of Aspergillus fumigatus causing necrotizing retinitis in an immunocompromised patient led to vision loss and death. Early vitrectomy with intravitreal amphotericin B is suggested for better treatment outcomes.

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Area of Science:

  • Ophthalmology
  • Mycology
  • Infectious Diseases

Background:

  • * Fungal infections can cause severe ocular disease, particularly in immunocompromised individuals.
  • * Aspergillus fumigatus is an opportunistic pathogen that can affect the eye.

Observation:

  • * A case of bilateral acute necrotizing retinitis caused by Aspergillus fumigatus is presented.
  • * The patient was immunocompromised and experienced rapid vision loss.
  • * Postmortem examination revealed extensive retinal and choroidal vascular occlusion by fungi and thrombi.

Findings:

  • * Light and electron microscopy confirmed Aspergillus fumigatus invasion, vascular occlusion, and retinal necrosis.
  • * Fungal hyphae were observed extending through retinal layers and on the iris surface.

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  • * Vitreous cultures were positive, while aqueous cultures were negative postmortem.

    • Implications:

    • * The extensive vascular involvement suggests limited drug penetration with conventional therapy.
    • * Early diagnostic vitrectomy combined with intravitreal amphotericin B is recommended.
    • * This approach may improve drug delivery to infected ocular sites and potentially alter patient outcomes.