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DIPNECH: Association Between Histopathology and Clinical Presentation
Rocco Trisolini1,2, Ilaria Valentini3, Carmine Tinelli4
1Interventional Pulmonology Unit, Policlinico Sant'Orsola-Malpighi, via Albertoni 15, 40138, Bologna, Italy. rocco.trisolini@aosp.bo.it.
Lung
|February 17, 2016
Summary
Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia (DIPNECH) can be found incidentally or cause symptoms. Symptomatic DIPNECH patients are younger and show more neuroendocrine cell proliferation and tumorlets on lung biopsy.
Area of Science:
- Pulmonology
- Pathology
- Radiology
Background:
- Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia (DIPNECH) is a rare lung disorder.
- It can be an incidental finding or diagnosed in patients with chronic obstructive symptoms.
Purpose of the Study:
- To investigate the association between histopathology and clinical presentation in DIPNECH.
- To differentiate between incidental and symptomatic DIPNECH cases.
Main Methods:
- Retrospective analysis of clinical, functional, radiological, and pathological data.
- 13 patients diagnosed with DIPNECH between 2000-2014 were included.
- Comparison of features between incidental and symptomatic DIPNECH.
Main Results:
- Symptomatic DIPNECH patients were younger (57.7 vs. 68.7 years) than incidental cases.
- Symptomatic patients showed more mosaic attenuation and small nodules on CT scans.
- Histopathology revealed a higher number of neuroendocrine proliferation foci and tumorlets in symptomatic cases.
- Incidental DIPNECH was associated with pulmonary adenocarcinoma in 83.3% of cases.
Conclusions:
- Symptomatic DIPNECH patients represent a distinct subgroup.
- This subgroup is characterized by younger age and a greater neuroendocrine cell proliferation burden.
