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Novel therapies for advanced squamous cell carcinoma of the lung

Konstantinos Koutsoukos1, Giannis Mountzios2

  • 1Medical Oncology Department, Alexandra Hospital, University of Athens School of Medicine, Athens, Greece.

Future Oncology (London, England)
|February 17, 2016
PubMed

Insights

Advanced squamous non-small-cell lung cancer (SqCC) treatment is improving. Genomic profiling reveals new targets, and immune checkpoint inhibitors show promise for better outcomes in advanced SqCC.

Area of Science:

  • Oncology
  • Genomics
  • Immunotherapy

Background:

  • Advanced squamous non-small-cell lung cancer (SqCC) historically lacked targeted therapies, lagging behind lung adenocarcinoma.
  • Systemic treatment progress for advanced SqCC has been limited, with combination chemotherapy as the current standard.
  • SqCC has been termed the 'neglected sibling' due to these therapeutic challenges.

Purpose of the Study:

  • To highlight the complex genomic profile of SqCC.
  • To explore novel targeted treatment strategies for advanced SqCC.
  • To discuss the emerging role of immune checkpoint inhibitors in SqCC treatment.

Main Methods:

  • Molecular characterization of SqCC to identify genetic alterations.
  • Review of recent clinical trial data for novel therapeutic agents.
  • Analysis of immune checkpoint inhibitor efficacy in various neoplasms.

Main Results:

  • SqCC exhibits a complex genomic landscape with potential molecular targets.
  • Immune checkpoint inhibitors demonstrate encouraging results in advanced SqCC.
  • Combination chemotherapy remains the established standard of care.

Conclusions:

  • The molecular characterization of SqCC opens avenues for targeted therapy development.
  • Immune checkpoint inhibitors represent a promising new treatment modality for advanced SqCC.
  • Personalized treatment strategies based on specific mutations are the future direction for SqCC management.
Keywords:
NSCLCnon-small-cell lung cancernovel therapiesreviewsquamous

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