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Updated: Mar 25, 2026

Detrusor Underactivity Model in Rats by Conus Medullaris Transection
Published on: August 28, 2020
Overactive Bladder
Nicola White1, Cheryl B Iglesia2
1Female Pelvic Medicine and Reconstructive Surgery, National Center for Advanced Pelvic Surgery, MedStar Washington Hospital Center, Georgetown University, 106 Irving Street, Northwest, Suite 405 South, Washington, DC 20010, USA.
Abstract:
Overactive bladder (OAB) is a condition affecting millions of individuals in the United States. Anticholinergics are the mainstay of treatment. Bladder botulinum toxin injections have shown an improvement in symptoms of OAB equivalent to anticholinergic therapy. Percutaneous tibial nerve stimulation can decrease symptoms of urinary frequency and urge incontinence. Sacral neuromodulation for refractory patients has been approved by the Food and Drug Administration for treatment of OAB, urge incontinence, and urinary retention. Few randomized, head-to-head comparisons of the different available alternatives exist; however, patients now have increasing options to manage their symptoms and improve their quality of life.
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