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Published on: June 23, 2019
Microwave-assisted Synthesis and antifungal activity of coumarin[8,7-e][1,3]oxazine derivatives
Ming-Zhi Zhang1, Rong-Rong Zhang1, Wen-Zheng Yin1
1Jiangsu Key Laboratory of Pesticide Science, College of Sciences, Nanjing Agricultural University, Nanjing, 210095, People's Republic of China.
Abstract:
The synthesis of novel coumarin[8,7-e][1,3]oxazine derivatives through a microwave-assisted three-component one-pot Mannich reaction is described in this study. All the target compounds were evaluated in vitro for their antifungal activity against Botrytis cinerea, Colletotrichum capsici, Alternaria solani, Gibberella zeae, Rhizoctonia solani, and Alternaria mali. The preliminary bioassays showed that 5e, 5m, and 5s exhibited good antifungal activity and the most active compound was 5m with an [Formula: see text] value as low as 2.1 nM against Botrytis cinerea.
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