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Vascular Endothelial Growth Factor Is Associated with the Morphologic and Functional Parameters in Patients with

Radek Pudil1, Martina Vasatova2, Alena Fucikova3

  • 11st Department of Internal Medicine-Cardioangiology, Faculty of Medicine in Hradec Kralove, Charles University in Prague, Sokolska 581, 500 05 Hradec Kralove, Czech Republic.

Biomed Research International
|February 17, 2016
PubMed

Insights

Vascular Endothelial Growth Factor (VEGF) is elevated in hypertrophic cardiomyopathy (HCM) patients. Higher VEGF levels correlate with significant structural and functional changes, suggesting its potential as a diagnostic marker for HCM.

Area of Science:

  • Cardiology
  • Molecular Biology

Background:

  • Hypertrophic cardiomyopathy (HCM) is a primary genetic heart muscle disease characterized by myocardial hypertrophy.
  • Vascular Endothelial Growth Factor (VEGF) plays a crucial role in myocyte function, growth, and survival.

Purpose of the Study:

  • To investigate the clinical significance of VEGF in relation to structural and functional alterations in patients diagnosed with HCM.

Main Methods:

  • Serum VEGF levels were measured in 21 patients with nonobstructive HCM and compared to healthy controls.
  • Associations between VEGF levels and morphological/functional parameters were analyzed using correlation coefficients.

Main Results:

  • Serum VEGF was significantly elevated in HCM patients (199 ng/L) compared to controls (20 ng/L), P < 0.001.
  • VEGF levels showed significant correlations with left atrium diameter (r=0.51), left ventricle ejection fraction (r=-0.56), left ventricular mass (r=0.61), inferior vena cava diameter (r=0.65), and tricuspid regurgitation (r=0.46).

Conclusions:

  • Elevated VEGF levels are linked to specific structural and functional changes observed in HCM patients.
  • VEGF may serve as a valuable biomarker in the diagnostic evaluation of hypertrophic cardiomyopathy.
Abstract

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