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Updated: Mar 25, 2026

Synthesis of a Thiol Building Block for the Crystallization of a Semiconducting Gyroidal Metal-sulfur Framework
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Bis(thiosemicarbazone) Metal Complexes as Therapeutics for Neurodegenerative Diseases

S Mckenzie-Nickson, A I Bush, K J Barnham1

  • 1Department of Pharmacology and Therapeutics, University of Melbourne, Melbourne, Australia. kbarnham@unimelb.edu.au.

Current Topics in Medicinal Chemistry
|February 17, 2016
PubMed

Insights

Bis(thiosemicarbazone) metal complexes show promise for treating neurodegenerative diseases like Alzheimer's and Parkinson's by correcting metal imbalance and reducing oxidative stress.

Area of Science:

  • Neuroscience
  • Pharmacology
  • Biochemistry

Background:

  • Neurodegenerative diseases are characterized by pathological protein aggregation and oxidative stress.
  • Transition metal dyshomeostasis is linked to these disease pathologies.
  • Targeting metal imbalance presents a potential therapeutic strategy.

Purpose of the Study:

  • To review the therapeutic potential of bis(thiosemicarbazone) metal complexes.
  • To discuss their efficacy in animal models of neurodegenerative diseases.
  • To explore future implications for these compounds.

Main Methods:

  • Review of existing scientific literature on bis(thiosemicarbazone) metal complexes.
  • Analysis of studies involving animal models of Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis.
  • Evaluation of compound properties such as oral bioavailability and blood-brain barrier penetration.

Main Results:

  • Bis(thiosemicarbazone) metal complexes are orally bioavailable and can cross the blood-brain barrier.
  • These compounds effectively deliver bioavailable metal intracellularly.
  • Successful treatment of animal models for Alzheimer's, Parkinson's, and ALS has been demonstrated.

Conclusions:

  • Bis(thiosemicarbazone) metal complexes represent a promising therapeutic class for neurodegenerative diseases.
  • Their ability to address metal dyshomeostasis and oxidative stress is key to their efficacy.
  • Further development holds significant implications for future neurodegenerative disease treatments.

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