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Updated: Mar 25, 2026
Isolation, Propagation, and Identification of Bacterial Species with Hydrocarbon Metabolizing Properties from Aquatic Habitats
Published on: December 7, 2021
Isolation and identification of berberine and berberrubine metabolites by berberine-utilizing bacterium Rhodococcus
Kazuki Ishikawa1, Hisashi Takeda1, Daigo Wakana1
1a Department of Organic Chemistry , Hoshi University , Tokyo , Japan.
Abstract:
Based on the finding of a novel berberine (BBR)-utilizing bacterium, Rhodococcus sp. strain BD7100, we investigated the degradation of BBR and its analog berberrubine (BRU). Resting cells of BD7100 demethylenated BBR and BRU, yielding benzeneacetic acid analogs. Isolation of benzeneacetic acid analogs suggested that BD7100 degraded the isoquinoline ring of the protoberberine skeleton. This work represents the first report of cleavage of protoberberine skeleton by a microorganism.
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