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Dual pH-responsive 5-aminolevulinic acid pseudopolyrotaxane prodrug micelles for enhanced photodynamic therapy
Hongxin Tong1, Yin Wang, Huan Li
1MOE Key Laboratory of Macromolecular Synthesis, Functionalization, Department of Polymer Science, Engineering, Zhejiang University, Hangzhou 310027, China. jinqiao@zju.edu.cn jijian@zju.edu.cn.
Chemical Communications (Cambridge, England)
|February 17, 2016
Abstract:
Novel 5-aminolevulinic acid (ALA) pseudopolyrotaxane prodrug micelles with dual pH-responsive properties were prepared by the host-guest interaction of α-cyclodextrin (α-CD) and poly(ethylene glycol) (PEG). The micelles exhibited pH dependent cellular uptake and pH-sensitive ALA release, enabling enhanced photodynamic therapy.
