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Design and Synthesis of a Reconfigurable DNA Accordion Rack
Published on: August 15, 2018
Cascade DNA logic device programmed ratiometric DNA analysis and logic devices based on a fluorescent dual-signal
Daoqing Fan1, Jinbo Zhu1, Qingfeng Zhai1
1State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin 130022, P. R. China. dongsj@ciac.ac.cn and University of Chinese Academy of Sciences, Beijing, 100039, China.
Abstract:
Herein, two fluorescence sensitive substrates of G-quadruplex/hemin DNAzyme with inverse responses (Scopoletin and Amplex Red) were simultaneously used in one homogeneous system to construct a cascade advanced DNA logic device for the first time (a functional logic device (a three input based DNA calliper) cascade with an advanced non-arithmetic logic gate (1 to 2 decoder)). This cascade logic device was applied to label-free ratiometric target DNA detection and length measurement.
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