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Updated: Mar 25, 2026
09:44
Neuro-rehabilitation Approach for Sudden Sensorineural Hearing Loss
Published on: January 25, 2016
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SOD1 gene polymorphisms in sudden sensorineural hearing loss.
Ryosuke Kitoh1, Shin-Ya Nishio1, Kaoru Ogawa2
1a Department of Otorhinolaryngology , Shinshu University School of Medicine , Matsumoto , Nagano , Japan ;
Acta Oto-Laryngologica
|February 17, 2016
Summary
Genetic variations in SOD1, specifically rs4998557, may increase the risk of sudden sensorineural hearing loss (SSNHL) in the Japanese population. This finding could aid in understanding SSNHL susceptibility.
Area of Science:
- Genetics
- Otolaryngology
- Molecular Biology
Background:
- Sudden sensorineural hearing loss (SSNHL) is a complex condition with potential genetic underpinnings.
- Identifying genetic factors associated with SSNHL is crucial for understanding disease mechanisms and susceptibility.
- Previous research has explored various candidate genes, but definitive associations remain elusive.
Purpose of the Study:
- To investigate the association between specific gene polymorphisms and susceptibility to sudden sensorineural hearing loss (SSNHL).
- To identify genetic markers that could predict the risk of developing SSNHL in a Japanese population.
Main Methods:
- A two-stage case-control study design was employed.
- Initially, 39 single nucleotide polymorphisms (SNPs) from 31 candidate genes were analyzed in 192 SSNHL patients and controls.
- Subsequently, significant SNPs, particularly within the SOD1 gene, were further examined in the second stage.
Main Results:
- Significant allele frequency differences were found for four SNPs in GSTP1, PRKCH, and SOD1 genes between SSNHL patients and controls.
- The SOD1 rs4998557 SNP showed a significant association with SSNHL in the dominant model.
- This association was more pronounced in SSNHL patients with hearing loss exceeding 60 dB and those experiencing tinnitus.
Conclusions:
- The SOD1 rs4998557 polymorphism is potentially associated with increased susceptibility to sudden sensorineural hearing loss (SSNHL).
- These findings contribute to the understanding of the genetic basis of SSNHL in the Japanese population.
- Further research is warranted to validate these genetic associations and explore their clinical implications.
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