[Correlation Study on Chinese Medical Syndrome Types of Chronic Atrophic Gastritis Patients, Hp, and IL-1β Polymorphism]
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Insights
Chinese medical syndrome types in chronic atrophic gastritis patients correlate with Helicobacter pylori infection and IL-1β levels, but not IL-1B gene polymorphism. This finding offers insights into gastritis pathogenesis.
Area of Science:
- Gastroenterology
- Immunology
- Genetics
Background:
- Chronic atrophic gastritis (CAG) is a significant precursor to gastric cancer.
- Helicobacter pylori (Hp) infection and host genetic factors, including IL-1B gene polymorphisms and IL-1β levels, are implicated in CAG development.
- Traditional Chinese Medicine (TCM) classifies CAG based on distinct syndrome types, which may reflect underlying pathophysiological differences.
Purpose of the Study:
- To investigate the association between specific Chinese Medicine (CM) syndrome types in CAG patients and Helicobacter pylori (Hp) infection.
- To examine the relationship between CM syndrome types, Hp infection, IL-1B gene polymorphisms, and IL-1β levels in CAG patients.
- To determine if IL-1B gene polymorphisms influence the risk of developing CAG.
Main Methods:
- A case-control study involving 192 CAG patients and 202 healthy controls.
- Hp infection detection using 13C-urea breath test and colloidal gold-labeled assay (GICA).
- Quantification of peripheral blood IL-1β by ELISA and analysis of IL-1B gene promoter polymorphisms via PCR-RFLP.
Main Results:
- Pi-Wei weakness syndrome (PWWS) was the most prevalent CM syndrome in CAG patients (31.77%).
- Hp infection was present in 53.65% of CAG patients, with higher rates in Pi-Wei damp-heat syndrome (PWDHS) and Gan-Wei disharmony syndrome (GWDS).
- Elevated plasma IL-1β levels were observed in CAG patients with PWDHS, GWDS, and static blood obstructing collaterals syndrome (SBOCS) compared to controls. No significant association was found between IL-1B gene polymorphisms and CAG.
Conclusions:
- IL-1B gene polymorphism is not associated with the incidence risk of CAG.
- CM syndrome types in CAG patients are significantly associated with Hp infection status.
- Peripheral blood IL-1β levels are linked to specific CM syndrome types in CAG patients, suggesting a role in disease pathogenesis.
Objective:
To explore the correlation between Chinese medical (CM) syndrome types of chronic atrophic gastritis (CAG) patients and Helicobacter pylori (Hp) infection, polymorphisms of IL-1B, and IL-1β.
Methods:
Totally 192 CAG patients and 202 healthy subjects (as the healthy control group) were recruited in this case-control study. The Hp infection was tested by 13C-urea breath test and colloidal gold-labeled assay (GICA). The concentration of peripheral blood IL-1β was measured by ELISA. The polymorphisms of IL-1B gene in the promoter region were analyzed using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP).
Results:
Pi-Wei weakness syndrome (PWWS) was dominant in CAG patients (31.77%, 61/192 cases). The Hp infection ratio in CAG patients was 53.65% (103/192 cases), of which, Pi-Wei damp-heat syndrome(PWDHS, 64.86%, 24/37 cases) and Gan-Wei disharmony syndrome (GWDS, 66.67%, 24/36 cases) were dominant. Compared with the health control group, the plasma concentration of IL-1β was obviously elevated in CAG patients with PWDHS, GWDS, and static blood obstructing collaterals syndrome (SBOCS) (all P < 0.05). Additionally, there was no difference in the distribution of polymorphisms in the promoter region of IL-1 B gene between the CAG patients and the healthy control group (P > 0.05).
Conclusions:
The incidence risk of CAG was not associated with IL-1B polymorphism. But CM syndrome types of CAG patients was associated with Hp infection and peripheral blood IL-1β levels.
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