Detection by light microscopy of Candida in thin sections of bladder stone
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H Takeuchi1, T Konishi, T Tomoyoshi
1Department of Urology, Shiga University of Medical Sciences, Japan.
Abstract:
We detected fungi morphologically resembling Candida albicans in an infected bladder stone by light microscopy of thin sections. The fungi were found in the layers precipitated with oxalate crystals and were invading the interstices surrounded with apatite or struvite crystals as in tissue infection. This presumably represents a superimposed infection due to changes in flora following treatment with antibiotics.
Insights
Fungi resembling Candida albicans were found within infected bladder stones, invading crystal layers. This suggests a secondary fungal infection may occur after antibiotic use.
Area of Science:
- Medical Mycology
- Urology
- Microbiology
Background:
- Bladder stones (calculi) can harbor microbial communities.
- Antibiotic therapy can alter the body's natural flora, potentially leading to opportunistic infections.
Observation:
- Microscopic examination of thin sections from an infected bladder stone revealed fungal elements.
- These fungi exhibited morphology consistent with Candida albicans.
Findings:
- The detected fungi were located within layers of the stone containing oxalate crystals.
- Fungal invasion was observed in the spaces between apatite or struvite crystals, mimicking tissue infection.
Implications:
- This finding suggests Candida albicans can infect bladder stones, potentially as a superimposed infection.
- Changes in microbial flora due to antibiotic treatment may predispose individuals to such fungal bladder stone infections.