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2016 European guideline on donovanosis.

Nigel O'Farrell1, Harald Moi2

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Donovanosis, a rare sexually transmitted infection, presents with genital ulcers. Diagnosis involves identifying Donovan bodies, and treatment with azithromycin is recommended for healing.

Keywords:
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Area of Science:

  • Infectious Diseases
  • Microbiology
  • Dermatology

Background:

  • Donovanosis is a rare sexually transmitted infection (STI).
  • Primarily caused by Calymmatobacterium granulomatis (proposed reclassification: Klebsiella granulomatis).
  • Mainly observed in sporadic cases in specific global regions.

Purpose of the Study:

  • To summarize the key aspects of Donovanosis.
  • To outline diagnostic methods and treatment recommendations.

Main Methods:

  • Microscopic identification of Donovan bodies on stained tissue smears.
  • Polymerase chain reaction (PCR) methods for diagnosis.

Main Results:

  • Incubation period averages 50 days.
  • Characterized by genital papules progressing to ulcers.
  • Four lesion types: ulcerogranulomatous, hypertrophic, necrotic, and sclerotic.

Conclusions:

  • Microscopic identification of Donovan bodies is a primary diagnostic tool.
  • Azithromycin is the recommended treatment, administered weekly until healing.