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Updated: Mar 25, 2026

Phenotypic Analysis and Isolation of Murine Hematopoietic Stem Cells and Lineage-committed Progenitors
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Hematopoietic stem cells: multiparameter regulation

Kedong Song1, Liying Li2, Yiwei Wang3

  • 1State Key Laboratory of Fine Chemicals, Dalian R&D Center for Stem Cell and Tissue Engineering, Dalian University of Technology, Dalian, 116024, China. kedongsong@dlut.edu.cn.

Human Cell
|February 18, 2016
PubMed

Hematopoietic stem cells (HSCs) are capable to self-renew with multi-potency which generated much excitement in clinical therapy. However, the main obstacle of HSCs in clinical application was insufficient number of HSCs which were derived from either bone marrow, peripheral blood or umbilical cord blood. This review briefly discusses the indispensable utility of growth factors and cytokines, stromal cells, extracellular matrix, bionic scaffold and microenvironment aiming to control the hematopoiesis in all directions and provide a better and comprehensive understanding for in vitro expansion of hematopoietic stem cells.

Keywords:
Ex vivo expansionHematopoietic stem cells (HSCs)Multiparameter regulation

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