A zwitterionic 1D/2D polymer co-crystal and its polymorphic sub-components: a highly selective sensing platform for
Hai-Qing Zhao1, Shui-Ping Yang1, Ni-Ni Ding2
1Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, P. R. China. jxchen@smu.edu.cn whchen@smu.edu.cn.
Dalton Transactions (Cambridge, England : 2003)
|February 18, 2016
Summary
New copper-based coordination polymers selectively detect HIV DNA. The P-DNA@3 system uses fluorescence quenching and recovery to identify specific DNA sequences with high sensitivity.
Area of Science:
- Coordination Chemistry
- Materials Science
- Biomedical Sensing
Background:
- Development of novel coordination polymers for advanced applications.
- Need for sensitive and selective methods for DNA detection.
Purpose of the Study:
- Synthesize and characterize novel copper(II) coordination polymers.
- Investigate their potential as fluorescent sensors for DNA detection.
Main Methods:
- Coordination reaction of a 2D polymer with copper nitrate.
- Structural characterization of resulting compounds (2-4).
- Fabrication and testing of a fluorescent DNA sensor (P-DNA@3 system).
Main Results:
- Three new polymorphic compounds (1D chain, 2D layer, co-crystal) were synthesized.
- The 2D layer compound (3) effectively interacted with probe single-stranded DNA (P-DNA).
- The P-DNA@3 system demonstrated selective fluorescence quenching and recovery for HIV double-stranded DNA (HIV ds-DNA) detection with a 1.42 nM limit.
Conclusions:
- Novel copper coordination polymers exhibit distinct structural diversity.
- The P-DNA@3 system serves as an efficient fluorescent sensor for HIV ds-DNA.
- The sensor can differentiate complementary DNA from mismatched sequences.
