Treatment of severe thyroid function disorders and changes in body composition.

Area of Science:

• Endocrinology
• Metabolic Medicine
• Body Composition Analysis

Background:

• Thyroid hormones regulate metabolic rate, thermogenesis, and body weight.
• Hyperthyroidism and hypothyroidism present with significant alterations in these physiological processes.

Purpose of the Study:

• To investigate the relationship between thyroid function normalization and body composition changes.
• To assess body composition shifts during treatment for severe hypo- and hyperthyroidism.

Main Methods:

• Body composition analysis and hormonal assessments were performed at diagnosis, 3 months, and recovery.
• Spearman correlation analysis examined relationships between thyroid hormones and body composition.

Main Results:

• Hypothyroid treatment reduced body weight primarily through fat mass decrease.
• Hyperthyroid treatment increased body weight, fat mass, muscle mass, and water mass.
• Thyroid hormone levels strongly correlated with total body weight and fat mass.

Conclusions:

• Body composition is intrinsically linked to thyroid hormone concentrations in thyroid dysfunction.
• Treatment-induced hormonal changes correlate directly with alterations in body weight, muscle, water, and fat mass.