Time-dependent irisin concentration changes in patients affected by overt hypothyroidism.

Area of Science:

• Endocrinology
• Metabolism
• Molecular Biology

Background:

• Irisin, a myokine derived from FNDC5, influences body metabolism.
• Thyroid function status may impact serum irisin levels.
• Existing data on irisin and hypothyroidism are inconsistent.

Purpose of the Study:

• To investigate time-dependent alterations in serum irisin levels.
• To assess irisin in overt hypothyroidism patients with varying durations.

Main Methods:

• Study included 36 subjects: 12 with long-lasting overt hypothyroidism (AITD), 12 with short-term overt hypothyroidism (TC), and 12 controls (CG).
• Measured serum irisin, thyrometabolic state, creatine kinase (CK), glucose, and insulin.
• Compared these parameters between the three groups.

Main Results:

• Irisin levels were significantly lower in AITD patients compared to TC and CG groups.
• No significant difference in irisin was found between TC and CG groups.
• Creatine kinase (CK) levels were higher in AITD patients, negatively correlating with irisin levels.

Conclusions:

• Irisin concentration changes appear to be time-dependent in thyroid dysfunction.
• Prolonged hypothyroidism is associated with lower serum irisin levels than short-term hypothyroidism.