Related Experiment Video
Updated: Mar 25, 2026

Murine Model of Allergen Induced Asthma
Published on: May 14, 2012
Asthma in an Adult Female Vervet Monkey (Chlorocebus sabaeus)
Liza S Köster1, Bradley Simon2, Gilda Rawlins3
1Department of Clinical Sciences, Ross University School of Veterinary Medicine, St Kitts and Nevis, West Indies. lkoster@rossvet.edu.kn.
Abstract:
A 9-y-old, colony-bred, female vervet monkey (Chlorocebus sabaeus) presented with a 6-y history of open-mouth breathing, tachypnea, and sibilant wheezing. These symptoms did not significantly affect her activity or quality of life. Thoracic radiographs and results of bronchoalveolar lavage supported the diagnosis of asthma. Treatment comprising intramuscular prednisolone (tapered over 2 mo from twice daily to every other day), inhaled salmeterol-fluticasone (25 μg-250 μg per actuation twice daily) by mask, and a metered dose inhaler was successful in restoring a normal respiratory pattern. Despite the availability of several primate models of human asthma, this case represents the first report of spontaneous asthma in a NHP.
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