Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Changes in the Appendicular Skeleton with Age01:09

Changes in the Appendicular Skeleton with Age

4.0K
The upper and lower limb initially develops as a small bulge called a limb bud, which appears on the lateral side of the early embryo. The upper limb bud appears near the end of the fourth week of development, with the lower limb bud appearing shortly after.
Initially, the limb buds consist of a core of mesenchyme covered by a layer of ectoderm. The ectoderm at the end of the limb bud thickens to form a narrow crest called the apical ectodermal ridge. This ridge stimulates the underlying...
4.0K
Bone Disorders01:29

Bone Disorders

7.1K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
7.1K
Development of the Limb Synovial Joints01:07

Development of the Limb Synovial Joints

2.7K
Joints form during embryonic development in conjunction with the formation and growth of the associated bones. The embryonic tissue that gives rise to all bones, cartilage, and connective tissues of the body is called mesenchyme.
The mesenchymal stem cells differentiate into chondrocytes that form the hyaline cartilage, and later the cartilaginous model of the bone. This model further transforms into a bone. This process is known as endochondral ossification.
During development, the limbs...
2.7K
Chronic Kidney Disease II: Clinical Manifestations01:24

Chronic Kidney Disease II: Clinical Manifestations

927
Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
927
Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation01:21

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

649
Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
649
Nephrotic Syndrome II : Assessment and Medical Management01:26

Nephrotic Syndrome II : Assessment and Medical Management

316
IntroductionNephrotic syndrome is a kidney disorder marked by excessive protein loss in the urine, leading to various systemic complications. This condition often results from damage to the glomeruli—the kidney's filtering units—causing proteinuria, low blood protein levels, and fluid retention. Understanding the assessment, diagnosis, and management of nephrotic syndrome is essential for effective treatment and prevention of further kidney damage.AssessmentPatient History: Document...
316

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Ultrasound-guided musculoskeletal interventions and professional boundaries: an international expert opinion.

European journal of physical and rehabilitation medicine·2026
Same author

Advancing Physical and Rehabilitation Medicine Education and Research in the Asia-Oceania Region: A Position Statement for Establishing the Asia-Oceania Academic Network of Physical and Rehabilitation Medicine.

American journal of physical medicine & rehabilitation·2026
Same author

Development of a World Health Organization indicator and corresponding questions to measure effective coverage of rehabilitation.

EClinicalMedicine·2025
Same author

Challenges in applying evidence-based practice in stroke rehabilitation: a qualitative description of health professional experience in low, middle, and high-income countries.

Disability and rehabilitation·2023
Same author

Ethical issues and dilemmas in spinal cord injury rehabilitation in the developing world: a mixed-method study.

Spinal cord·2022
Same author

Cochrane Rehabilitation: 2020 annual report.

European journal of physical and rehabilitation medicine·2021

Related Experiment Video

Updated: Mar 25, 2026

Tissue Collection and RNA Extraction from the Human Osteoarthritic Knee Joint
06:06

Tissue Collection and RNA Extraction from the Human Osteoarthritic Knee Joint

Published on: July 22, 2021

7.1K

Ochronotic Arthropathy: Two Case Reports from a Developing Country.

Farooq A Rathore1, Saeed B Ayaz2, Sahibzada N Mansoor3

  • 1Department of Rehabilitation Medicine, CMH Lahore Medical College and Institute of Dentistry, Lahore, Pakistan.

Clinical Medicine Insights. Arthritis and Musculoskeletal Disorders
|February 18, 2016
PubMed
Summary

Alkaptonuria, a rare metabolic disorder, causes homogentisic acid buildup, leading to ochronosis and joint issues. Early diagnosis of this orphan disease can improve patient quality of life despite limited treatment options.

Keywords:
Pakistanalkaptonuriahomogentisic acidochronosisorphan diseaseosteoarthritis

More Related Videos

A Reproducible Cartilage Impact Model to Generate Post-Traumatic Osteoarthritis in the Rabbit
08:42

A Reproducible Cartilage Impact Model to Generate Post-Traumatic Osteoarthritis in the Rabbit

Published on: November 21, 2023

2.0K
Standardized Histomorphometric Evaluation of Osteoarthritis in a Surgical Mouse Model
07:32

Standardized Histomorphometric Evaluation of Osteoarthritis in a Surgical Mouse Model

Published on: May 6, 2020

13.5K

Related Experiment Videos

Last Updated: Mar 25, 2026

Tissue Collection and RNA Extraction from the Human Osteoarthritic Knee Joint
06:06

Tissue Collection and RNA Extraction from the Human Osteoarthritic Knee Joint

Published on: July 22, 2021

7.1K
A Reproducible Cartilage Impact Model to Generate Post-Traumatic Osteoarthritis in the Rabbit
08:42

A Reproducible Cartilage Impact Model to Generate Post-Traumatic Osteoarthritis in the Rabbit

Published on: November 21, 2023

2.0K
Standardized Histomorphometric Evaluation of Osteoarthritis in a Surgical Mouse Model
07:32

Standardized Histomorphometric Evaluation of Osteoarthritis in a Surgical Mouse Model

Published on: May 6, 2020

13.5K

Area of Science:

  • Biochemistry
  • Genetics
  • Metabolic Disorders

Background:

  • Alkaptonuria is a rare, inherited metabolic disorder.
  • It stems from a deficiency in the homogentisate 1,2-dioxygenase enzyme.
  • This deficiency leads to homogentisic acid accumulation throughout the body.

Observation:

  • Two cases presented with ochronotic arthropathy and secondary osteoarthritis.
  • Patients exhibited intervertebral disk calcifications, skin, and scleral pigmentation.
  • Diagnosis was delayed, with symptoms present for over a decade in both cases.

Findings:

  • Conservative management included ascorbic acid, exercise, and gait aids.
  • The first patient showed some symptomatic improvement.
  • The second patient was lost to follow-up, limiting outcome assessment.

Implications:

  • Alkaptonuria, while not directly impacting mortality, significantly affects quality of life.
  • Early diagnosis is crucial for managing symptoms and improving patient outcomes.
  • Further research into effective treatments for this rare orphan disease is warranted.