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VKORC1 and CD-14 genetic polymorphisms associate with susceptibility to cardiovascular and cerebrovascular diseases

Jian Du1, Zhiguo Zhang1, Yuanyuan Ge1

  • 1Department of Geriatrics, The First Hospital of Jilin University Changchun 130021, P. R. China.

International Journal of Clinical and Experimental Medicine
|February 18, 2016
PubMed

Insights

Genetic variations in VKORC1 and CD-14 may influence susceptibility to cardiovascular and cerebrovascular diseases (CCVD). Specific haplotypes like CAT and TAT appear to be risk factors, while TAC and TGC may offer protection.

Area of Science:

  • Genetics and Cardiovascular Epidemiology
  • Molecular Biology and Disease Susceptibility

Background:

  • Cardiovascular and cerebrovascular diseases (CCVD) represent a significant global health burden.
  • Genetic factors play a crucial role in the susceptibility to CCVD.
  • Understanding specific gene polymorphisms and their associations is vital for risk stratification and prevention.

Purpose of the Study:

  • To investigate the association between specific genetic polymorphisms in VKORC1 (rs2359612, rs9923231) and CD-14 (rs2569190) and the risk of developing CCVD.
  • To identify potential genetic markers for CCVD susceptibility.

Main Methods:

  • A case-control study involving 614 CCVD patients and 590 healthy controls.
  • Genotyping of VKORC1 and CD-14 polymorphisms using Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP).
  • Haplotype and logistic regression analyses were performed using SHEsis software to identify risk factors.

Main Results:

  • Statistically significant differences in genotype and allele frequencies for VKORC1 rs2359612, rs9923231, and CD-14 rs2569190 between cases and controls (P<0.05).
  • Haplotype analysis revealed CAT and TAT as risk haplotypes, and TAC and TGC as protective haplotypes for CCVD (P<0.05).
  • Logistic regression identified age, systolic pressure, smoking history, and VKORC1 rs2359612 as potential risk factors, while BMI, diastolic pressure, and VKORC1 rs9923231 as potential protective factors.

Conclusions:

  • VKORC1 rs2359612 and rs9923231, along with CD-14 rs2569190, are potentially associated with CCVD susceptibility.
  • The identified haplotypes (CAT, TAT, TAC, TGC) may serve as genetic indicators for CCVD risk or protection.
Abstract

Keywords:
CD-14 gene polymorphismLogistic regression analysisVKORC1 gene polymorphismcardiovascular and cerebrovascular diseaseshaplotype analysisrs2359612rs2569190rs9923231

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