Related Experiment Video
Updated: Mar 25, 2026
Genome-Wide Analysis of DNA Methylation in Gastrointestinal Cancer
Published on: September 18, 2020
Microsatellite instability of gastric cancer and precancerous lesions
Bing Li1, Hong-Yi Liu1, Shao-Hua Guo1
1Department of Surgical Oncology, General Hospital of The People's Liberation Army No. 28, Fuxing Road, Beijing 100853, P.R. China.
Objective:
To investigate whether microsatellite instability (MSI) of gastric cancer and precancerous lesions were existed and its effect.
Methods:
Laser microdissection was used. Gastric, intestinal metaplasia, dysplasia and normal mucosa were collected respectively. Five microsatellite loci were selected and MSI was detected by denaturing high-performance liquid chromatography.
Results:
In the five microsatellite loci REF-positive phenotype, intestinal metaplasia MSI was 20.7%. Dysplasia MSI was 22.4%. Gastric MSI was 47.9%, and there was no MSI in normal gastric mucosa.
Conclusion:
MSI gradually increased from precancerous lesions to gastric cancer. The early detection of MSI may be a potential early warning indicator for early diagnosis of gastric cancer.
