Related Experiment Video
Updated: Mar 25, 2026
Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty
Published on: January 28, 2020
Correlation between mimecan expression and coronary artery stenosis in patients with coronary heart disease
Youdong Hu1, Junying Liu1, Qingna Zhao1
1Department of Geriatrics, Affiliated Huai'ai Hospital of Xuzhou Medical Collage Huai'an, China.
Insights
Increased Mimecan and nuclear factor kappaB (NF-κB) expression in coronary heart disease (CHD) patients correlates with disease severity. These elevated levels suggest a link to cardiac insufficiency in patients with coronary artery stenosis.
Area of Science:
- Cardiovascular Research
- Biochemistry
- Molecular Biology
Background:
- Coronary heart disease (CHD) involves coronary artery stenosis.
- Mimecan and nuclear factor kappaB (NF-κB) are implicated in vascular pathologies.
Purpose of the Study:
- To investigate the correlation between coronary artery stenosis severity and Mimecan expression in CHD patients.
- To assess the relationship between NF-κB expression and coronary artery stenosis.
Main Methods:
- Enzyme-linked immunosorbent assay (ELISA) was used to measure serum Mimecan and NF-κB levels.
- Seventy-eight CHD patients and 80 controls were included.
- CHD patients were stratified into one-vessel, two-vessel, and multivessel disease subgroups.
Main Results:
- Serum Mimecan and NF-κB levels were significantly higher in CHD patients compared to controls (P < 0.05).
- Mimecan and NF-κB expression increased progressively with the severity of coronary lesions, from one-vessel to multivessel disease (P < 0.05).
- Positive correlations were found between Mimecan/NF-κB levels and the extent of coronary artery stenosis (rmimecan=0.79, rNF-κB=0.83, P < 0.05).
Conclusions:
- Elevated serum Mimecan and NF-κB expression in CHD patients are associated with cardiac insufficiency.
- The binding of NF-κB to the Mimecan gene may contribute to the observed cardiac insufficiency in CHD.
Objective:
This study aimed to investigate the correlation between coronary artery stenosis and Mimecan expression in patients with coronary heart disease (CHD).
Methods:
Seventy eight patients with CHD and 80 controls without vascular lesions were recruited into present study. CHD patients were divided into one-vessel CHD subgroup, 2-vessel CHD subgroup and multivessel CHD subgroup. ELISA was performed to detect the expressions of serum Mimecan and nuclear factor kappaB (NF-κB).
Results:
When compared with control group, the expressions of serum mimecan gene and NF-κB significantly increased in CHD groups (P < 0.05); When compared with one-vessel and two-vessel CHD subgroups, the expressions of serum mimecan and NF-κB significantly increased in multivessel CHD subgroup (P < 0.05), significant difference was observed among three subgroups (P < 0.05). The expressions of serum mimecan and NF-κB were positively related to the severity of coronary lesions (rmimecan=0.79, rNF-κB=0.83, P < 0.05).
Conclusion:
Increased expressions of serum mimecan and NF-κB in CHD patients are related to cardiac insufficiency, which may be ascribed to the binding of NF-κB to mimecan gene.
More Related Videos
06:16Signal Acquisition, Score Interpretation, and Economics of a Non-Invasive Point-of-Care Test for Coronary Artery Disease
Published on: August 9, 2024
06:39Ultrasound Based Assessment of Coronary Artery Flow and Coronary Flow Reserve Using the Pressure Overload Model in Mice
Published on: April 13, 2015
Related Concept Videos
01:30Coronary Artery Disease III: Clinical Manifestations
01:25Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT
01:30Coronary Artery Disease I: Introduction
01:26Coronary Artery Disease II: Pathophysiology
01:30Acute Coronary Syndrome III: Diagnostic Studies
01:23Mitral Stenosis II: Clinical features and Diagnostic Tests