Carotid atherosclerosis is associated with hypertension in a hospital-based retrospective cohort
Aoya Liu1, Zhenqiu Yu1, Ning Wang1
1Hypertension Clinic, Capital Medical University Affiliated Beijing Anzhen Hospital No. 2 Anzhen Road, Beijing 100029, China.
Insights
Carotid artery plaque is linked to blood pressure variation, particularly systolic pressure changes. This finding highlights the importance of monitoring blood pressure variability in cardiovascular health.
Area of Science:
- Cardiovascular Medicine
- Hypertension Research
- Vascular Biology
Background:
- Carotid artery plaque is a significant indicator of atherosclerosis.
- Blood pressure variability is increasingly recognized as a cardiovascular risk factor.
Purpose of the Study:
- To investigate the association between carotid artery plaque and blood pressure variation.
- To identify other cardiovascular risk factors linked to carotid plaque formation.
Main Methods:
- Retrospective analysis of clinical data from 408 hypertensive inpatients.
- Inclusion of carotid ultrasonography, demographic, and clinical data.
- Statistical analysis including multivariate regression.
Main Results:
- 55.1% of patients had carotid artery plaque, increasing with age.
- Plaque prevalence correlated with disease duration, blood glucose, total cholesterol, and LDL-C.
- Systolic blood pressure variation, but not diastolic, was significantly associated with plaque prevalence.
Conclusions:
- Carotid atherosclerosis is independently associated with blood pressure variation.
- The coefficient of systolic blood pressure variation is a key predictor of carotid plaque.
Objective:
We aim to investigate the association between carotid artery plaque and blood pressure variation, as well as other cardiovascular risk factors.
Materials And Methods:
We retrospectively analyzed clinical data of inpatients with high blood pressure treated in the Department of Hypertension from April 2009 to June 2010. Results from carotid ultrasonography, demographic characteristics, and other clinical data were obtained from 408 patients.
Results:
(1) The rate of positive plaque in carotid artery was 55.1%, and there was no difference between men and women. However, this rate was positively correlated with the age of the patients. (2) The rate of positive plaque in carotid artery was associated with the duration of the disease, fasting blood-glucose levels, total cholesterol, and low-density lipoprotein-cholesterol (LDL-C). (3) The prevalence of carotid artery plaque increased in accordance with the coefficient of systolic pressure variation (X(2) = 15.83, P = 0.001), whereas no correlation existed between prevalence of carotid artery plaque and coefficient of diastolic pressure variation and the plaque prevalence (X(2) = 0.24, P = 0.97). Mean systolic blood pressure (MSBP) was positively correlated with prevalence of carotid artery plaque (X(2) = 10.47, P = 0.005). (4) Multivariate regression analysis indicated that carotid plaque was associated with the age, duration of hypertension, high-density lipoprotein-cholesterol (HDL-C), LDL-C, 24 h MSBP, and coefficient of systolic pressure variation, whereas no associations were found with the coefficient of diastolic pressure variation, 24 h average diastolic blood pressure (AvDP), and 24 h mean arterial pressure (MAP) (P > 0.05).
Conclusion:
Carotid atherosclerosis was independently associated with variation of blood pressure, especially with coefficient of systolic blood pressure variation.
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