Related Experiment Video
Updated: Mar 25, 2026
Assessment of Vascular Function in Patients With Chronic Kidney Disease
Published on: June 16, 2014
Oxidative Stress Biomarkers and Left Ventricular Hypertrophy in Children with Chronic Kidney Disease
Dorota Drożdż1, Przemko Kwinta2, Krystyna Sztefko3
1Dialysis Unit, Jagiellonian University Medical College, 265 Wielicka Street, 30-663 Krakow, Poland.
Insights
Oxidized low-density lipoprotein (oxLDL) levels are linked to cardiovascular risks and left ventricular hypertrophy in children with chronic kidney disease (CKD). These findings highlight oxLDL as a key marker for oxidative stress in pediatric CKD patients.
Area of Science:
- Pediatric Nephrology
- Cardiovascular Research
- Oxidative Stress Biomarkers
Background:
- Cardiovascular diseases are a leading cause of death in children with chronic kidney disease (CKD).
- Oxidative stress plays a significant role in the development of cardiovascular complications in CKD.
- Left ventricular hypertrophy (LVH) is a common cardiovascular manifestation in pediatric CKD.
Purpose of the Study:
- To investigate the association between oxidative stress biomarkers and cardiovascular risk factors.
- To assess the relationship between oxidative stress and left ventricular hypertrophy (LVH) in children with CKD.
- To evaluate the utility of serum oxidized low-density lipoprotein (oxLDL) as a marker in this population.
Main Methods:
- Studied 65 children (ages 1.4-18.6 years) with stages 1-5 CKD.
- Measured serum levels of oxLDL, protein carbonyls, creatinine, cystatin C, lipids, hs-CRP, ICAM-1, insulin, PRA, and aldosterone.
- Performed anthropometric measurements, ambulatory blood pressure monitoring, and echocardiography for left ventricular mass (LVM) calculation.
Main Results:
- Serum oxLDL showed significant correlations with creatinine, cystatin C, total cholesterol, triglycerides, and LDL concentrations.
- Elevated oxLDL levels were strongly associated with 24-hour systolic, diastolic, and mean arterial blood pressure.
- A significant correlation was observed between oxLDL levels and left ventricular mass (LVM) z-scores.
Conclusions:
- Hypertension and dyslipidemia are linked to lipid oxidation in pediatric CKD.
- Serum oxLDL is a valuable biomarker for oxidative stress in children with CKD.
- Oxidative stress, indicated by oxLDL, correlates with left ventricular hypertrophy in this patient group.
Abstract:
Cardiovascular diseases remain the most frequent cause of morbidity and mortality in patients with chronic kidney disease (CKD). The aim of the study was to assess the association between oxidative stress biomarkers and cardiovascular risk factors and left ventricular hypertrophy in children with CKD. Material and Methods. The studied group consisted of 65 patients aged 1.4-18.6 (mean 11.2) years with stages 1 to 5 CKD. Serum oxidized low-density lipoprotein (oxLDL), protein carbonyl group, creatinine, cystatin C, albumin, lipids, high-sensitivity C-reactive protein, intercellular adhesion molecule-1, insulin, plasma renin activity, and aldosterone levels were measured. Patients were divided into groups depending on CKD stage. Anthropometric measurements, ambulatory blood pressure (BP) measurements, and echocardiography with left ventricular mass (LVM) calculation were performed. Results. Serum oxLDL strongly correlated with creatinine (R = 0.246; p = 0.048), cystatin C (R = 0.346; p = 0.006), total cholesterol (R = 0.500; p < 0.001), triglycerides (R = 0.524; p < 0.001), low-density lipoprotein concentrations (R = 0.456; p < 0.001), and 24 hour BP values of systolic (R = 0.492; p = 0.002), diastolic (R = 0.515; p < 0.001), and mean arterial pressure (R = 0.537; p < 0.001). A significant correlation between oxLDL levels and LVM z-scores (R = 0.299; p = 0.016) was found. Conclusions. Hypertension and dyslipidemia correlated with lipid oxidation in children with CKD. oxLDLs seem to be valuable markers of oxidative stress in CKD patients, correlating with left ventricular hypertrophy.
More Related Videos
Related Concept Videos
01:25Chronic Kidney Disease I: Introduction
01:19Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
01:24Chronic Kidney Disease II: Clinical Manifestations
01:30Acute Kidney Injury IV: Diagnostic Studies and Prevention
01:29Heart Failure II: Pathophysiology
01:20Blood Studies for Cardiovascular System I: Cardiac Biomarkers
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...