Related Experiment Video
Updated: Mar 25, 2026
05:32
Author Spotlight: Assessing Ischemic Stroke Damage Through Middle Cerebral Artery Occlusion Model
Published on: August 11, 2023
3.3K
Cognitive Impairment in Transient Ischemic Attack Patients: A Systematic Review
Frank G van Rooij1, Roy P C Kessels, Edo Richard
1Department of Neurology, Radboud University Medical Center, Donders Institute for Brain, Cognition and Behaviour, Centre for Neuroscience, Nijmegen, The Netherlands.
Cerebrovascular Diseases (Basel, Switzerland)
|February 18, 2016
Summary
Transient ischemic attack (TIA) can lead to cognitive impairment in many patients, with mild impairment affecting over a third. Executive functions are particularly impacted, though causes remain unclear.
Area of Science:
- Neurology
- Neuroscience
- Cognitive Science
Background:
- Transient ischemic attack (TIA) is defined by symptoms resolving within 24 hours.
- However, cognitive complaints frequently persist after TIA symptom resolution.
- The prevalence, causes, and specific profile of post-TIA cognitive impairment are not well understood.
Purpose of the Study:
- To systematically review the existing literature on cognitive impairment following TIA.
- To determine the prevalence and characteristics of cognitive deficits after TIA.
- To identify potential factors influencing post-TIA cognitive outcomes.
Main Methods:
- A systematic review of Medline and Embase databases was conducted.
- Thirteen studies investigating cognitive impairment after TIA were included.
- Risk of bias was assessed, and data were synthesized based on cognitive impairment severity.
Main Results:
- Prevalence of mild cognitive impairment post-TIA ranged from 29% to 68%.
- Severe cognitive impairment was observed in 8% to 22% of patients.
- Executive function deficits were prominent, but data on causality and neuroimaging correlation were limited.
Conclusions:
- Mild cognitive impairment is common after TIA, with a profile resembling vascular cognitive impairment.
- Cognitive impairment rates vary significantly, with screening tools detecting higher frequencies.
- Heterogeneity and limited data restrict definitive conclusions on causative factors and long-term outcomes.
