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Epilepsy and Seizures: Overview

Epilepsy and Seizures: Overview

Epilepsy is a chronic neurological disease marked by recurrent, unpredictable seizures. These seizures are caused by abnormal electrical discharges in the brain, leading to behavior, sensation, or consciousness alterations. They can also cause transient impairment of awareness, interfering with daily activities.
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...

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Related Experiment Video

Updated: Mar 25, 2026

Author Spotlight: Advancing Pediatric Epilepsy Surgery in Children Through Novel Biomarkers and Enhanced Localization

Author Spotlight: Advancing Pediatric Epilepsy Surgery in Children Through Novel Biomarkers and Enhanced Localization

Published on: September 20, 2024

Predicting epilepsy surgery outcome.

Philippe Ryvlin¹, Sylvain Rheims

¹aDepartment of Clinical Neurosciences, CHUV, Lausanne, Switzerland bEpilepsy Institute (IDEE) cDepartment of Functional Neurology and Epileptology, Hospices Civils de Lyon dLyon's Neuroscience Research Center, Lyon, France.

Current Opinion in Neurology

|February 18, 2016

Summary

This summary is machine-generated.

Epilepsy surgery offers improved seizure control, with serious complications below 1%. Advances in neuroimaging and identifying "temporal plus epilepsy" are key to predicting outcomes and improving patient quality of life.

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A Pipeline for 3D Multimodality Image Integration and Computer-assisted Planning in Epilepsy Surgery

A Pipeline for 3D Multimodality Image Integration and Computer-assisted Planning in Epilepsy Surgery

Published on: May 20, 2016

Area of Science:

Neurosurgery
Epileptology
Neurology

Background:

Epilepsy surgery aims to improve seizure control and quality of life.
Recent advancements have focused on refining surgical techniques and patient selection.

Purpose of the Study:

To review current evidence on seizure, safety, cognitive, and psychosocial outcomes of epilepsy surgery.
To identify predictors of successful epilepsy surgery outcomes.

Main Methods:

Systematic review of recent literature on epilepsy surgery outcomes.
Analysis of data on seizure freedom, complication rates, cognitive function, and psychosocial well-being.

Main Results:

Serious surgical complications are now below 1% for temporal lobe resections.
Long-term seizure control may exceed 80% in select epilepsy types (e.g., mesial temporal lobe epilepsy, FCD type 2).
MRI-negative epilepsy and "temporal plus epilepsy" are identified as predictors of surgical failure.

Conclusions:

Advances in neuroimaging and understanding of specific epilepsy types improve outcome prediction.
Optimizing surgical candidacy and managing comorbidities are crucial for cognitive and quality-of-life outcomes.