Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Structure and Function of Platelets01:18

Structure and Function of Platelets

4.6K
The cell fragments known as platelets are disc-shaped, with an average diameter of about 3 μm and a thickness of roughly 1 μm. They play a crucial role in the body's vascular clotting system, which also involves plasma proteins, blood cells, and blood vessel tissues.
Platelets are continually replenished, circulating in the bloodstream for 9-12 days before being removed by phagocytes, primarily in the spleen. A microliter of circulating blood contains between 150,000 and 450,000...
4.6K
Formation of the Platelet Plug01:22

Formation of the Platelet Plug

10.6K
The platelet phase, the second stage of hemostasis, commences around 15-20 seconds after an injury. It follows and overlaps with the vascular phase, during which blood vessels constrict to minimize blood loss.
As the injured blood vessel contracts, endothelial cells undergo contraction, revealing collagen fibers in the basement membrane and underlying connective tissue. Furthermore, the plasma membrane of endothelial cells becomes adhesive, preparing the site for platelet adhesion. Platelets...
10.6K
Disorders of Hemostasis01:24

Disorders of Hemostasis

2.7K
Hemostasis, the process that stops bleeding after a blood vessel injury, is crucial for maintaining the integrity of the circulatory system. However, disorders of hemostasis can disrupt this delicate balance, leading to either excessive clotting or bleeding. These disorders can be broadly classified into thromboembolic disorders and bleeding disorders.
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.
2.7K
Anticoagulant Drugs: Low-Molecular-Weight Heparins01:30

Anticoagulant Drugs: Low-Molecular-Weight Heparins

2.3K
Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
2.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Post-operative venous thromboembolism in advanced epithelial ovarian cancer: risk factors, tumor gene expression, and survival.

International journal of gynecological cancer : official journal of the International Gynecological Cancer Society·2026
Same author

Von Willebrand disease: A century of progress.

Research and practice in thrombosis and haemostasis·2026
Same author

Therapeutic Strategies Combining Antiplatelet With Anticoagulant Actions: Heparin Proteoglycan Mimetic APAC as a Model.

Arteriosclerosis, thrombosis, and vascular biology·2026
Same author

Preoperative Biomarker Panel With Fibrinogen, FVIII, and CA 19-9 as a Tool for Prognostic Evaluation in Neoadjuvant-Treated Pancreatic Ductal Adenocarcinoma.

Cancer medicine·2026
Same author

Seventh Åland Island Meeting on von Willebrand Disease.

Haemophilia : the official journal of the World Federation of Hemophilia·2026
Same author

Interactions of dual antiplatelet and anticoagulant with C1q and FH regulate complement activation by injured cells.

Blood vessels, thrombosis & hemostasis·2026

Related Experiment Video

Updated: Mar 25, 2026

A Microfluidic Flow Chamber Model for Platelet Transfusion and Hemostasis Measures Platelet Deposition and Fibrin Formation in Real-time
09:38

A Microfluidic Flow Chamber Model for Platelet Transfusion and Hemostasis Measures Platelet Deposition and Fibrin Formation in Real-time

Published on: February 14, 2017

14.5K

Platelet Function Tests in Bleeding Disorders.

Riitta Lassila1

  • 1Coagulation Disorders, Hematology, Comprehensive Cancer Center, Helsinki University Hospital, Helsinki University, Helsinki, Finland.

Seminars in Thrombosis and Hemostasis
|February 18, 2016
PubMed
Summary

Platelet function disorders impact numerous physiological aspects, affecting bleeding and clotting. Comprehensive assessment is crucial for managing bleeding risks and guiding interventions.

Area of Science:

  • Hematology
  • Clinical Pathology
  • Hemostasis and Thrombosis

Background:

  • Platelet functional disorders encompass diverse abnormalities in platelet physiology.
  • These disorders can affect platelet number, production, destruction, adhesion, activation, and aggregation.

Purpose of the Study:

  • To outline the scope of platelet functional disorders and their clinical implications.
  • To review current diagnostic approaches and their limitations.
  • To emphasize the importance of comprehensive assessment for effective management.

Main Methods:

  • Review of platelet physiology and functional disorder manifestations.
  • Analysis of current diagnostic tools including blood cell counts, aggregometry (WBA, LTA), and platelet function analysis (PFA-100).

More Related Videos

Microfluidics in Assessing Platelet Function
06:47

Microfluidics in Assessing Platelet Function

Published on: November 8, 2024

1.8K
Microfluidic Flow Chambers Using Reconstituted Blood to Model Hemostasis and Platelet Transfusion In Vitro
10:25

Microfluidic Flow Chambers Using Reconstituted Blood to Model Hemostasis and Platelet Transfusion In Vitro

Published on: March 19, 2016

10.1K

Related Experiment Videos

Last Updated: Mar 25, 2026

A Microfluidic Flow Chamber Model for Platelet Transfusion and Hemostasis Measures Platelet Deposition and Fibrin Formation in Real-time
09:38

A Microfluidic Flow Chamber Model for Platelet Transfusion and Hemostasis Measures Platelet Deposition and Fibrin Formation in Real-time

Published on: February 14, 2017

14.5K
Microfluidics in Assessing Platelet Function
06:47

Microfluidics in Assessing Platelet Function

Published on: November 8, 2024

1.8K
Microfluidic Flow Chambers Using Reconstituted Blood to Model Hemostasis and Platelet Transfusion In Vitro
10:25

Microfluidic Flow Chambers Using Reconstituted Blood to Model Hemostasis and Platelet Transfusion In Vitro

Published on: March 19, 2016

10.1K

  • Discussion of limitations in assay standardization and quality control.

    • Main Results:

    • Platelet function assays, while varied, face challenges in standardization and quality control.
    • Validated methods include whole blood aggregometry (WBA), light transmission aggregometry (LTA), and platelet function analysis (PFA-100).
    • Current assays often simplify platelet behavior by isolating them from their natural environment.

    Conclusions:

    • Platelet function testing should follow a thorough clinical bleeding assessment.
    • The primary goal of assessing platelet function disorders is to optimize hemostasis management for interventions and bleeding events.
    • Achieving highly specific diagnoses in routine clinical practice can be challenging but is vital for genetic counseling.