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Meta-Analysis of the Effects of Xingnaojing Injection on Consciousness Disturbance
Lijun Wu1, Hua Zhang, Yanwei Xing
1From the Key Laboratory of Chinese Internal Medicine of Ministry of Education and Beijing (LW, YG, XR, BN, LZ, HS); Key office of Encephalopathy TCM Research (LW, HZ, YG, LZ, Ying Gao), State Administration of Traditional Chinese Medicine, Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine; Guang'anmen Hospital (YX, YL), Chinese Academy of Chinese Medical Sciences, Beijing; and Shandong University of Traditional Chinese Medicine (JL), Jinan, China.
Abstract:
Xingnaojing (XNJ) is commonly extracted from Angongniuhuang, a classic Chinese emergency prescription, and widely used in the treatment of nervous system disorders including consciousness disturbance in China. To evaluate the beneficial and adverse effects of XNJ injection, on consciousness disturbance. Seven major electronic databases were searched to retrieve randomized controlled trials designed to evaluate the clinical efficacy of XNJ alone or combined with Western medicine in treating consciousness disturbance caused by conditions such as high fever, poisoning, and stroke. The methodological quality of the included studies was assessed using criteria from the Cochrane Handbook for Systematic Review of Interventions, and analyzed using the RevMan 5.3.0 software. Seventeen randomized controlled trials on XNJ were included in this study and the trials generally showed low methodological quality. The results revealed that XNJ alone or in combination with other medicines and adjuvant methods had a positive effect on patients with fever-, poisoning-, and stroke-induced coma. XNJ effectively treated consciousness disturbances that were caused by high fever, poisoning, or stroke.
