Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Video

Updated: Mar 25, 2026

Spontaneous and Evoked Measures of Pain in Murine Models of Monoarticular Knee Pain

Spontaneous and Evoked Measures of Pain in Murine Models of Monoarticular Knee Pain

Published on: February 22, 2019

Methods for measuring pain in laboratory animals.

Dustin M Graham

|February 18, 2016

Summary

Measuring animal pain is crucial for ethical research. Advances in behavioral neuroscience are improving the accuracy and automation of objective pain assessments in laboratory animals.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Layer- and Cell Type-Specific Response Properties of Gustatory Cortex Neurons in Awake Mice.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2020

Same author

Non-conforming, part 1: ICD-11.

The lancet. Psychiatry·2019

Same author

Small structures on a big scale.

Lab animal·2018

Same author

A new window sheds light on lung tumor metastasis.

Lab animal·2018

Same author

An "off-the-shelf" biological vascular graft.

Lab animal·2018

Same author

Tracking the proteome in specific cell-types in vivo.

Lab animal·2018

Area of Science:

Animal Science
Neuroscience
Pain Research

Background:

Pain management is a key ethical consideration in laboratory animal science.
Accurate pain assessment in non-verbal animal models is challenging but critical for research.
Objective pain measurement is essential for animal welfare and scientific validity.

Purpose of the Study:

To highlight the importance of objective pain measurement in laboratory animals.
To discuss recent advancements in behavioral neuroscience for pain assessment.
To emphasize the need for consistent, automated, and accurate pain evaluation methods.

Main Methods:

Review of developments in behavioral neuroscience relevant to pain assessment.
Focus on techniques enabling objective and automated measurement of pain.
Exploration of methods applicable to non-verbal animal models.

Main Results:

Behavioral neuroscience offers improved tools for pain assessment.
New methods enhance consistency, automation, and accuracy in measuring animal pain.
Developments facilitate more reliable pain evaluation in animal models.

Conclusions:

Recent advancements significantly improve objective pain measurement in laboratory animals.
These developments are vital for ethical animal research and reliable scientific outcomes.
The field is moving towards more consistent, automated, and accurate pain assessment strategies.

More Related Videos

Mechanical Conflict-Avoidance Assay to Measure Pain Behavior in Mice

Mechanical Conflict-Avoidance Assay to Measure Pain Behavior in Mice

Published on: February 18, 2022

Development of Recombinant Proteins to Treat Chronic Pain

Development of Recombinant Proteins to Treat Chronic Pain

Published on: April 11, 2018

Related Experiment Videos

Last Updated: Mar 25, 2026

Spontaneous and Evoked Measures of Pain in Murine Models of Monoarticular Knee Pain

Spontaneous and Evoked Measures of Pain in Murine Models of Monoarticular Knee Pain

Published on: February 22, 2019

Mechanical Conflict-Avoidance Assay to Measure Pain Behavior in Mice

Mechanical Conflict-Avoidance Assay to Measure Pain Behavior in Mice

Published on: February 18, 2022

Development of Recombinant Proteins to Treat Chronic Pain

Development of Recombinant Proteins to Treat Chronic Pain

Published on: April 11, 2018