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Related Experiment Videos

Thrombosis in atherogenesis.

K L Kaplan1, A Bini

  • 1Department of Medicine, Columbia-Presbyterian Medical Center, New York, New York.

Critical Reviews in Oncology/Hematology
|January 1, 1989
PubMed
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Fibrin plays a role in atherosclerosis development. Studies show fibrinogen transforms into fibrin and degradation products within arterial walls, contributing to plaque formation and progression.

Area of Science:

  • Cardiovascular Biology
  • Pathology
  • Biochemistry

Background:

  • Previous studies indicated fibrinogen/fibrin presence in atherosclerotic plaques.
  • Limited techniques hindered differentiation between fibrinogen, fibrin, and degradation products.
  • The origin of plaque fibrinogen (thrombi incorporation vs. vessel wall entry) was debated.

Purpose of the Study:

  • To investigate the role of fibrin in atherosclerotic plaque development.
  • To differentiate fibrinogen, fibrin I, fibrin II, and degradation products in plaques.
  • To elucidate the localization and formation of fibrin within the arterial wall.

Main Methods:

  • Utilized specific antibodies against fibrinopeptides to quantify fibrinogen and fibrin forms.
  • Employed sensitive immunohistochemical techniques with monoclonal antibodies.

Related Experiment Videos

  • Analyzed fibrinogen-related antigen distribution in normal and atherosclerotic aortas.

    • Main Results:

    • Normal aortas contained fibrinogen; fatty and fibrous plaques showed fibrinogen, fibrin I, and fibrin II.
    • Complicated plaques contained fibrin II and fragment X, indicating progression.
    • Immunohistochemistry revealed thrombi incorporation and fibrin formation associated with arterial wall cells.

    Conclusions:

    • Fibrinogen progresses to fibrin and degradation products with increasing plaque severity.
    • Fibrin formation appears to occur within the arterial wall.
    • Fibrin contributes to atherosclerotic plaque formation and progression.