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Related Concept Videos

Peripheral Artery Disease I: Introduction01:30

Peripheral Artery Disease I: Introduction

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Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs, particularly the arteries supplying the thighs and calves. In rare cases, it may involve other arteries, including those in the arms.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty...
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Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation01:21

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

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Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
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Coronary Artery Disease I: Introduction01:30

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Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
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Peripheral Artery Disease IV: Nursing Management01:26

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 The nursing management of a patient with peripheral artery disease (PAD) begins with a thorough assessment of the patient’s health history and clinical manifestations.AssessmentHealth History: Evaluate the patient’s history of hypertension, hyperlipidemia, family history of cardiovascular issues, and lifestyle factors such as dietary patterns, smoking, and physical activity.Physical Examination:Assess the affected extremity for decreased or absent peripheral pulses,...
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Atherosclerosis II: Clinical Manifestations and Diagnostic Tests01:27

Atherosclerosis II: Clinical Manifestations and Diagnostic Tests

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Atherosclerosis is a progressive disorder that leads to the thickening and narrowing of arterial walls due to plaque buildup. This condition can cause various symptoms depending on the arteries affected:Coronary Artery Disease (CAD): This condition affects the coronary arteries and may lead to chest pain (angina), shortness of breath (dyspnea), heart attacks, and other heart disease symptoms.Cerebrovascular Disease: This affects blood flow to the brain, causing transient ischemic attacks (TIAs)...
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Peripheral Artery Disease III: Interprofessional Care01:27

Peripheral Artery Disease III: Interprofessional Care

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Peripheral Artery Disease (PAD) is characterized by narrowed arteries that diminish blood flow to the extremities. Effective management of PAD requires an interprofessional approach involving various healthcare professionals. The critical aspects of interprofessional care for PAD patients focus on risk factor modification, drug therapy, exercise therapy, nutrition therapy, critical limb ischemia care, and interventional radiology and surgical procedures.The primary treatment goal for PAD...
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Related Experiment Video

Updated: Mar 25, 2026

Author Spotlight: The Significance of Isolation, Culture, and Adipogenic Induction of SVF-Derived Preadipocytes from Mouse Perivascular Adipose Tissue
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Epigenetics and Peripheral Artery Disease.

Jonathan Golledge1,2, Erik Biros3, John Bingley4,5

  • 1The Vascular Biology Unit, Queensland Research Centre for Peripheral Vascular Disease, College of Medicine & Dentistry, James Cook University, Townsville, QLD, 4811, Australia. jonathan.golledge@jcu.edu.au.

Current Atherosclerosis Reports
|February 19, 2016
PubMed
Summary
This summary is machine-generated.

Epigenetic factors, like microRNAs, are linked to peripheral artery diseases. Modifying these epigenetic changes may improve patient outcomes in the future.

Keywords:
Abdominal aortic aneurysmDNA methylationEpigeneticsPeripheral artery diseasemicroRNAs

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Area of Science:

  • Epigenetics and Molecular Biology
  • Cardiovascular Research

Background:

  • Peripheral artery diseases (PAD), including lower limb artery disease and abdominal aortic aneurysm, are influenced by risk factors like smoking and age.
  • Epigenetic modifications, such as non-coding RNAs, DNA methylation, and histone modifications, are inheritable changes in gene function without altering DNA sequence.

Purpose of the Study:

  • To review studies associating epigenetic factors with PAD.
  • To examine the impact of epigenetic modifications on PAD outcomes in mouse models.

Main Methods:

  • Literature review focusing on microRNAs, DNA methylation, and histone modifications in relation to PAD.
  • Analysis of mouse model studies investigating epigenetic intervention effects on PAD.

Main Results:

  • Several circulating microRNAs have been identified as biomarkers associated with human PAD.
  • Modulating specific microRNAs in mouse models has shown potential in limiting aortic aneurysm and hind limb ischemia.
  • The role of DNA methylation and histone modifications in PAD remains understudied.

Conclusions:

  • Circulating microRNAs show promise as diagnostic markers for PAD.
  • Epigenetic modifications, particularly microRNAs, represent potential therapeutic targets for improving PAD outcomes.
  • Further research is needed to validate microRNAs for patient identification and therapeutic intervention in PAD.