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Related Concept Videos

Brain Imaging01:14

Brain Imaging

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Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans),  magnetic resonance imaging (MRI),  functional magnetic resonance imaging (fMRI), and Transcranial Magnetic...
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Serial Two-Photon Tomography of the Whole Marmoset Brain for Neuroanatomical Analyses
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Modern Methods for Interrogating the Human Connectome.

Mark J Lowe1, Ken E Sakaie1, Erik B Beall1

  • 11Imaging Institute,Cleveland Clinic,Cleveland,Ohio.

Journal of the International Neuropsychological Society : JINS
|February 19, 2016
PubMed
Summary
This summary is machine-generated.

This review explores brain connectivity research methods, covering functional MRI, diffusion MRI, and electroencephalography/magnetoencephalography. It critically analyzes techniques for studying the human connectome in healthy and disordered brains.

Keywords:
Complex network analysisDiffusion MRIEEG/MEG coherenceHuman connectomeIndependent components analysisResting state fMRI

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Area of Science:

  • Neuroscience
  • Cognitive Science

Background:

  • Connectionist theories of brain function, pioneered by Norman Geschwind, have evolved significantly.
  • Modern neuroimaging has spurred increased interest in studying brain connectivity in both healthy and disordered states.

Purpose of the Study:

  • To provide an introduction to evaluating scientific methods for human connectome investigations.
  • To critically analyze common techniques and analytical approaches in brain connectivity research.

Main Methods:

  • Review of common techniques: resting-state functional MRI, diffusion MRI, electroencephalography (EEG) and magnetoencephalography (MEG) coherence.
  • Examination of analytical approaches for assessing brain interconnectivity.

Main Results:

  • Critical analysis of assumptions and methodological limitations for each imaging and analysis approach.
  • Highlights the strengths and weaknesses of current brain connectivity measurement techniques.

Conclusions:

  • Equips readers with the knowledge to critically assess research on the human connectome.
  • Emphasizes the importance of understanding methodological underpinnings in brain connectivity studies.