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Related Experiment Video

Updated: Mar 25, 2026

Development of Obliterative Bronchiolitis in a Murine Model of Orthotopic Lung Transplantation
10:01

Development of Obliterative Bronchiolitis in a Murine Model of Orthotopic Lung Transplantation

Published on: July 10, 2012

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Lung transplantation for diffuse panbronchiolitis: 5 cases from a single centre.

Seiichiro Sugimoto1, Kentaroh Miyoshi2, Masaomi Yamane2

  • 1Department of General Thoracic Surgery, Okayama University Hospital, Kita-ku, Okayama, Japan sugimo-s@cc.okayama-u.ac.jp.

Interactive Cardiovascular and Thoracic Surgery
|February 19, 2016
PubMed
Summary

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Recurrence of Pulmonary Hypertension After Unilateral Lung Transplantation: Histological Evidence of Vasoconstrictive Mechanism.

Pulmonary circulation·2026
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Determination of the Side Responsible for Bilateral Pneumothorax due to Pleural Communication.

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Radiological Predictors of Visceral Pleural Invasion in Lung Cancers With Ground-Glass Opacity and Pleural Contact.

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Diagnostic Value of Quantitative Lung Perfusion Single-photon Emission CT/CT for Chronic Lung Allograft Dysfunction in Patients After Bilateral Lung Transplantation.

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Risk Factors for Waiting List Mortality in Lung Transplant Candidates With Post-Hematopoietic Stem Cell Transplantation Non-Infectious Pulmonary Complications.

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Tailored Management of Anomalous Systemic Arterial Supply to the Basal Segment of the Lung: A Case Report and Literature Review.

Surgical case reports·2026

Lung transplantation offers a viable treatment for diffuse panbronchiolitis when macrolide therapy fails. This study shows positive survival outcomes in patients undergoing lung transplants for this rare genetic respiratory disease.

Area of Science:

  • Pulmonology
  • Transplant Surgery
  • Genetics

Background:

  • Diffuse panbronchiolitis is a rare genetic respiratory disease primarily affecting East Asians.
  • Characterized by chronic inflammation of respiratory bronchioles and sinobronchial infections.
  • Long-term macrolide therapy improves survival, but some patients progress to requiring lung transplantation.

Purpose of the Study:

  • To evaluate the outcomes of lung transplantation in patients with diffuse panbronchiolitis.
  • To assess the viability and safety of lung transplantation for progressive disease unresponsive to macrolides.

Main Methods:

  • Retrospective analysis of 5 patients with diffuse panbronchiolitis who underwent lung transplantation.
  • Patients received long-term macrolide therapy and had preoperative Pseudomonas aeruginosa colonization.
Keywords:
Bronchiolitis obliteransLung infectionLung transplantationOutcomesRecurrenceRejection

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  • Procedures included bilateral cadaveric (4 patients) and living-donor (1 patient) lung transplantation.

    • Main Results:

    • All 5 patients survived with a median follow-up of 4.9 years.
    • One patient experienced acute rejection (A3), and another developed chronic lung allograft dysfunction.
    • No patients developed severe pneumonia, fatal infections, or recurrence of diffuse panbronchiolitis.

    Conclusions:

    • Lung transplantation is a feasible and effective treatment option for diffuse panbronchiolitis refractory to macrolide therapy.
    • Transplantation offers a chance for long-term survival in patients with end-stage disease.
    • Careful patient selection and management are crucial for successful outcomes.