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Updated: Mar 25, 2026
A Simple Bioassay for the Evaluation of Vascular Endothelial Growth Factors
Published on: March 15, 2016
[Concentration of plasma vascular endothelial growth factor and related factors in patients with unstable angina
Wenfang He1, Zhe Wang1, Jun Cai1
1Department of Cardiology, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China.
Insights
Plasma vascular endothelial growth factor (VEGF) is elevated in unstable angina pectoris (UAP) patients. Higher VEGF levels correlate with coronary artery stenosis and poorer vascular function, suggesting its potential as a biomarker.
Area of Science:
- Cardiology
- Biochemistry
- Vascular Biology
Background:
- Unstable angina pectoris (UAP) is a critical manifestation of coronary heart disease (CHD).
- Understanding the underlying biochemical markers is crucial for diagnosis and risk stratification.
- Vascular endothelial growth factor (VEGF) plays a role in angiogenesis and vascular integrity.
Purpose of the Study:
- To investigate plasma vascular endothelial growth factor (VEGF) levels in patients with unstable angina pectoris (UAP).
- To identify factors associated with elevated VEGF in UAP patients.
- To explore the potential of VEGF as a biomarker for coronary artery lesions.
Main Methods:
- 108 patients with chest pain were categorized into UAP (n=78) and non-CHD (n=30) groups based on coronary angiography.
- Plasma VEGF levels, homocysteine (Hcy), serum lipids, and reactive hyperemia index (RHI) were measured.
- Gensini score assessed coronary artery stenosis severity; multiple linear regression analyzed VEGF correlations.
Main Results:
- UAP patients exhibited significantly higher plasma VEGF levels (102.1 ± 55.7 ng/L vs. 80.9 ± 38.1 ng/L) and lower RHI (1.53 ± 0.27 vs. 1.65 ± 0.32) compared to the non-CHD group.
- Higher triglyceride and Hcy levels were observed in the UAP group.
- VEGF levels significantly correlated with the degree of coronary artery stenosis, Gensini score, and RHI.
Conclusions:
- Plasma VEGF levels are significantly elevated in patients with unstable angina pectoris (UAP).
- VEGF is significantly associated with coronary artery stenosis severity and impaired vascular function (RHI).
- VEGF may serve as a novel biochemical indicator for assessing coronary artery lesions in UAP patients.
Objective:
To observe plasma vascular endothelial growth factor(VEGF) levels and related factors in patients with unstable angina pectoris(UAP).
Methods:
A total of 108 consecutive patients with chest pain hospitalized in our department from October to December 2014 were included. They were divided into UAP (n=78) and non-CHD group (n=30) by the result of coronary angiography(CAG). Coronary artery lesion was assessed according to the Gensini score, serum lipids, homocysteine(Hcy) levels and other biochemical indicators were also determined. The peripheral arterial tonometry was evaluated by reactive hyperemia index(RHI) measured by Endo-PAT2000 Noninvasive Diagnostic System.The level of plasma VEGF was detected in patients with unstable angina pectoris. Multiple linear regression analysis was used to analyze the correlations between VEGF and various related factors.
Results:
Percent of male gender, triglyceride (TG) and Hcy levels were significantly higher in UAP group than in no-CHD group(all P<0.05). VEGF values was significantly higher ((102.1 ± 55.7)ng/L vs.(80.9 ± 38.1)ng/L, P<0.05), while RHI was significantly lower (1.53 ± 0.27 vs.1.65 ± 0.32, P<0.05) in UAP group than in no-CHD group. Multiple linear regression analysis showed that VEGF value was significantly correlated with degree of coronary artery stenosis, Gensini score and RHI (β=38.03, P<0.01; β=0.51, P<0.01; β=-69.30, P=0.03; respectively).
Conclusion:
VEGF levels are significantly increased in patients with unstable angina pectoris, and VEGF level is significantly associated with the degree of coronary artery stenosis, Gensini score and RHI. V EGF level might serve as a new biochemical indicator for coronary artery lesion in patients with UAP.
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