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Related Concept Videos

Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

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Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
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Microbiota of the Respiratory Tract01:29

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The human respiratory tract, comprising the upper and lower segments, serves as a critical interface with the external environment. The upper respiratory tract (URT)—including the nostrils, sinuses, pharynx, and oropharynx—is heavily colonized by microbes, while the lower respiratory tract (LRT), composed of the larynx, trachea, bronchi, and lungs, was long thought to be sterile. However, recent molecular studies have revealed that the lungs are not devoid of microbes but act more...
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Obesity01:24

Obesity

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The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
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Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

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Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
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Asthma-I: Introduction01:29

Asthma-I: Introduction

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Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
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Asthma-IV: Diagnostic and Management01:30

Asthma-IV: Diagnostic and Management

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The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
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Related Experiment Video

Updated: Mar 25, 2026

Intraperitoneal Glucose Tolerance Test, Measurement of Lung Function, and Fixation of the Lung to Study the Impact of Obesity and Impaired Metabolism on Pulmonary Outcomes
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Obesity, Asthma, and the Microbiome.

Youngji Cho1, Stephanie A Shore2

  • 1Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.

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Obesity worsens asthma, and standard treatments are less effective in obese individuals. This study explores how gut and lung microbes may influence this condition, potentially leading to new therapies.

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Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing
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Isolation, Characterization, and Purification of Macrophages from Tissues Affected by Obesity-related Inflammation
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Area of Science:

  • Microbiology
  • Pulmonology
  • Metabolic disorders

Background:

  • Obesity is a known risk factor for asthma.
  • Standard asthma medications show reduced effectiveness in obese patients.
  • Obesity-induced alterations in the gut microbiome are linked to various health issues.

Purpose of the Study:

  • To investigate the potential role of gut and lung microbiota in obesity-related asthma.
  • To explore how microbial community structure changes in obesity might impact asthma development and severity.
  • To identify potential novel therapeutic targets for asthma in obese individuals.

Main Methods:

  • Review of existing literature on obesity, asthma, and microbiome.
  • Analysis of microbial community structure in gastrointestinal and pulmonary systems.
  • Correlation studies between microbial alterations and asthma phenotypes in obese populations (hypothetical).

Main Results:

  • Obesity significantly alters the gastrointestinal microbial community.
  • These microbial changes may contribute to obesity-related comorbidities, including asthma.
  • The lung microbiota in obese individuals remains an understudied area with potential implications for asthma.

Conclusions:

  • Microbiota dysbiosis in obesity could be a key factor in the reduced efficacy of asthma treatments.
  • Further research into the lung microbiota is crucial for understanding obesity-related asthma.
  • Targeting microbial communities may offer novel therapeutic strategies for managing asthma in obese patients.