Relationship of coronary collateral circulation with eosinophils in patients with unstable angina pectoris
Jun Wang1, Qun Li2, Shi-jing Li1
1Department of Cardiology, Beijing Mentougou District Hospital, Capital Medical University, Beijing, People's Republic of China.
Insights
Increased eosinophils (EOS) are linked to better coronary collateral circulation (CCC) in unstable angina patients. Higher EOS counts may promote the development of high-grade CCC, indicating a potential role in cardiovascular health.
Area of Science:
- Cardiovascular Medicine
- Hematology
- Angiology
Background:
- Eosinophils (EOS) are linked to prognosis in coronary artery disease.
- Plentiful coronary collateral circulation (CCC) is associated with favorable clinical outcomes.
- The relationship between EOS and CCC is not well-established.
Purpose of the Study:
- To investigate the association between EOS and the development of CCC.
- To explore the role of EOS in patients with unstable angina pectoris (UAP).
Main Methods:
- 502 consecutive UAP patients with coronary stenosis ≥80% were analyzed.
- Coronary angiography was performed, and CCC was graded using the Rentrop system (0-3).
- Patients were categorized into low-grade (Rentrop 0-1) and high-grade (Rentrop 2-3) CCC groups.
Main Results:
- EOS counts were significantly higher in the high-grade CCC group versus the low-grade CCC group.
- EOS (OR: 1.969) and neutrophil count (OR: 0.757) were independent predictors of high-grade CCC.
- EOS >0.12×10(9)/L independently predicted high-grade CCC with 72.5% sensitivity and 58.4% specificity (AUC: 0.681).
Conclusions:
- EOS are associated with high-grade CCC in UAP patients with significant coronary stenosis.
- Elevated EOS counts may play a crucial role in promoting CCC development in UAP.
Background:
Eosinophils (EOS) have been associated with prognosis of patients with coronary artery disease, and those who showed plenitudinous coronary collateral circulation (CCC) often have good clinical consequences. However, the relationship between EOS and CCC was seldom reported.
Objective:
To investigate the relationship between EOS and CCC development in patients with unstable angina pectoris (UAP).
Methods:
The study population consisted of 502 consecutive patients with UAP who underwent coronary angiography and coronary stenosis ≥80%. CCC was graded according to the Rentrop grading system of 0-3. Rentrop grades of 0 and 1 indicated low-grade CCC group, whereas grades 2 and 3 indicated high-grade CCC group.
Results:
The EOS was significantly higher in the high-grade CCC group compared with the low-grade CCC group. In multiple logistic regression analysis, EOS (odds ratio: 1.969; 95% confidence interval [CI]: 1.210-3.3205; P=0.006) and neutrophil count (odds ratio: 0.757; 95% CI: 0.584-0.981; P=0.035) were predictors of high-grade CCC development. EOS of >0.12×10(9)/L could independently predict high-grade CCC with 72.5% sensitivity and 58.4% specificity (area under the curve: 0.681; 95% CI: 0.632-0.729).
Conclusion:
EOS were associated with high-grade CCC in patients with UAP with coronary stenosis ≥80%. Increased EOS count may play an important role in the development of CCC in patients with UAP.
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