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Target morphology and cell memory: a model of regenerative pattern formation.
Nikolai Bessonov1, Michael Levin2, Nadya Morozova3
1Institute of Problems of Mechanical Engineering, Russian Academy of Sciences, 199178 Saint Petersburg, Russia.
Neural Regeneration Research
|February 19, 2016
Summary
This study explores pattern regeneration mechanisms, proposing two cell memory models. These models explain how regenerating tissues recognize correct morphology and stop growth, crucial for complex anatomical repair in animals.
Area of Science:
- Developmental Biology
- Regenerative Medicine
- Systems Biology
Background:
- Understanding complex anatomical regeneration remains a challenge.
- Key question: how do regenerating systems know when to stop growth and remodeling?
Purpose of the Study:
- Review two conceptual models of pattern regeneration.
- Propose mechanisms based on cell memory for pattern correction and structural regeneration.
Main Methods:
- Model 1: All cells communicate, track total received signal, and initiate regeneration based on signal distribution changes.
- Model 2: Coordinator cells in tissues communicate, retaining memory of signals dependent on cell location to guide regeneration.
Main Results:
- Both models implement pattern memory for regeneration.
- Model 1 uses error minimization via signaling memory.
- Model 2 utilizes coordinator cell communication and memory for structural correction.
Conclusions:
- Cell memory is a plausible mechanism for pattern regeneration.
- These models are compatible with diverse molecular implementations in organisms.
- Further research can explore specific molecular pathways underlying these memory mechanisms.
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