A case of membranous nephropathy as a manifestation of graft-versus-host disease

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Jae Hyun Han1, Hyoung Rae Kim1, Gi Jeong Kim2

  • 1Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.

Kidney Research and Clinical Practice
|February 19, 2016
PubMed

Nephrotic syndrome (NS) rarely occurs after hematopoietic stem cell transplantation (HSCT) as a late manifestation of graft-versus-host disease (GVHD). Herein, we report a case of HSCT-associated membranous nephropathy in a female patient with aplastic anemia. The patient received an allogeneic HSCT from her human leukocyte antigen-identical brother following myeloablative conditioning chemotherapy. NS occurred 21 months after HSCT without any concurrent features of chronic GVHD. The patient was treated with prednisolone and cyclosporine after renal biopsy confirmed membranous nephropathy, and achieved complete remission. Our report contradicts previous assumptions that concomitant chronic GVHD is responsible for the development of NS, suggesting that NS can develop as a new, independent manifestation of GVHD.

Keywords:
Graft-versus-host diseaseMembranous nephropathyNephrotic syndrome

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