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Tuberculosis Risk among Medical Trainees, Pune, India
Emerging Infectious Diseases
|February 19, 2016
Abstract:
During 2012-2013, at a public hospital in Pune, India, 26 (3.9%) cases of tuberculosis were reported among 662 medical trainees, representing an estimated incidence of 3,279 cases/100,000 person-years. Three of these infections were isoniazid-resistant, 1 was multidrug-resistant, and 1 occurred in a trainee who had fulminant hepatitis after starting treatment for TB.
Insights
Tuberculosis (TB) incidence was high among medical trainees in Pune, India, with 3.9% infected. Some cases showed drug resistance or severe treatment complications.
Area of Science:
- Public Health
- Infectious Diseases
- Occupational Health
Background:
- Medical trainees are a vulnerable population for infectious diseases due to potential exposure in healthcare settings.
- Understanding tuberculosis (TB) incidence in this demographic is crucial for implementing targeted prevention strategies.
- Previous data on TB among medical trainees in India may be limited.
Purpose of the Study:
- To determine the incidence of tuberculosis among medical trainees at a public hospital in Pune, India.
- To identify drug resistance patterns in tuberculosis cases within this cohort.
- To document any severe adverse events associated with TB treatment in medical trainees.
Main Methods:
- A retrospective study was conducted over a 1-year period (2012-2013) at a public hospital.
- Data were collected on all medical trainees (n=662) working at the institution.
- Tuberculosis cases were identified, and drug resistance profiles (including isoniazid and multidrug resistance) were analyzed.
Main Results:
- A total of 26 cases of tuberculosis (3.9%) were reported among 662 medical trainees.
- The estimated incidence rate was 3,279 cases per 100,000 person-years.
- Drug resistance was observed in 4 cases: 3 isoniazid-resistant and 1 multidrug-resistant.
- One trainee experienced fulminant hepatitis after initiating TB treatment.
Conclusions:
- Medical trainees in Pune, India, exhibit a significant burden of tuberculosis.
- The presence of drug-resistant TB highlights the need for vigilant surveillance and appropriate treatment regimens.
- Severe treatment complications like hepatitis underscore the importance of close monitoring during TB therapy in this population.
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