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Identification of a novel HLA-B*40 allele, HLA-B*40:324, by sequence-based typing, in a Chinese individual

J Zou1, W Qiang1, G Shen1

  • 1HLA Typing Laboratory, Wuhan Blood Center, Wuhan, China.

HLA
|February 19, 2016
PubMed

Keywords:
HLA-B*40:324novel allelesequence-based typing

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A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...